Sorrell T C, Forbes I J, Burness F R, Rischbieth R H
Lancet. 1971 Dec 4;2(7736):1233-5. doi: 10.1016/s0140-6736(71)90547-2.
63 patients on long-term oral therapy with phenytoin sodium (sodium diphenylhydantoin) were screened for abnormalities of immunological function. They were compared with 92 controls and 28 patients with lymphoma. Depression of cellular or humoral immunity, or both, was found in a significant number of phenytoin-treated and lymphoma subjects. Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D.H.S.) to three common skin-test antigens (22%), and depression of in-vitro lymphocyte transformation by phytohaemagglutinin (27%). Lymphoma patients manifested low IgM (22%), and inability to make antibody to S. typhi (11%) and to tetanus toxoid (21%). D.H.S. was absent in 36%; lymphocyte transformation was depressed in 17%. Abnormal lymphocyte transformation did not correlate with depression of cellular or humoral immunity in either group.
对63例长期口服苯妥英钠（二苯乙内酰脲钠）的患者进行了免疫功能异常筛查。将他们与92名对照者以及28例淋巴瘤患者进行比较。在大量接受苯妥英治疗的患者和淋巴瘤患者中发现了细胞免疫或体液免疫或两者均有抑制。苯妥英治疗与低免疫球蛋白A（21%）、对伤寒沙门菌抗原的抗体反应缺失（9%）、对三种常见皮肤试验抗原无迟发型超敏反应（D.H.S.）（22%）以及植物血凝素诱导的体外淋巴细胞转化受抑制（27%）相关。淋巴瘤患者表现出低IgM（22%），以及无法产生针对伤寒沙门菌（11%）和破伤风类毒素（21%）的抗体。36%的患者无D.H.S.；17%的患者淋巴细胞转化受抑制。两组中异常的淋巴细胞转化均与细胞免疫或体液免疫的抑制无关。
