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N-demethylation of lergotrile by Streptomyces platensis.普拉特链霉菌对麦角腈的N-去甲基化作用。
Appl Environ Microbiol. 1979 Nov;38(5):891-3. doi: 10.1128/aem.38.5.891-893.1979.
2
Physiologic disposition of lergotrile.麦角腈的生理处置
Clin Pharmacol Ther. 1978 Mar;23(3):272-80. doi: 10.1002/cpt1978233272.
3
Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.伯氨喹：微生物代谢及¹³C核磁共振归属
Antimicrob Agents Chemother. 1981 Feb;19(2):337-41. doi: 10.1128/AAC.19.2.337.
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Microbial transformations of pergolide to pergolide sulfoxide and pergolide sulfone.培高利特向培高利特亚砜和培高利特砜的微生物转化。
J Pharm Sci. 1983 Jul;72(7):733-6. doi: 10.1002/jps.2600720704.
5
Microbial transformations and 13C-NMR analysis of colchicine.
J Pharm Sci. 1979 Oct;68(10):1239-43. doi: 10.1002/jps.2600681011.
6
Lergotrile in Parkinson disease: further studies.麦角腈用于帕金森病：进一步研究
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Microbial N-demethylation: biotransformation and recovery of a drug metabolite.微生物N-去甲基化：一种药物代谢物的生物转化与回收
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G7063-2, a new nitrogen-containing antibiotic of the epoxydon group, isolated from the fermentation broth of a species of Streptomyces.
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Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.链霉菌中 RNA 聚合酶抑制剂链雷菌素的生物合成：3-甲基天冬氨酸的修饰改造。
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本文引用的文献

1
The isolation and structural elucidation of liatrin, a novel antileukemic sesquiterpene lactone from Liatris chapmanii.
J Org Chem. 1973 May 18;38(10):1853-8. doi: 10.1021/jo00950a017.
2
Microbial models of mammalian metabolism.
J Pharm Sci. 1975 Nov;64(11):1737-59. doi: 10.1002/jps.2600641104.
3
Galactorrhea: a study of 235 cases, including 48 with pituitary tumors.溢乳症：235例研究，其中48例患有垂体肿瘤。
N Engl J Med. 1977 Mar 17;296(11):589-600. doi: 10.1056/NEJM197703172961103.
4
Role of ergot derivatives in the treatment of parkinsonism.麦角衍生物在帕金森病治疗中的作用。
Fed Proc. 1978 Jun;37(8):2207-9.
5
Studies with lergotrile mesylate in acromegaly.甲磺酸麦角腈在肢端肥大症中的研究。
Fed Proc. 1978 Jun;37(8):2198-201.
6
The van urk-Salkowski reagent--a sensitive and specific chromogenic reagent for silica gel thin-layer chromatographic detection and identification of indole derivatives.范·厄克-萨尔科夫斯基试剂——一种用于硅胶薄层色谱检测和鉴定吲哚衍生物的灵敏且特异的显色试剂。
J Chromatogr. 1977 Feb 11;132(2):267-76. doi: 10.1016/s0021-9673(00)89300-0.
7
Studies on the antiparkinsonism efficacy of lergotrile.麦角腈抗帕金森病疗效的研究。
Neurology. 1975 May;25(5):459-62. doi: 10.1212/wnl.25.5.459.
8
Metabolism of lergotrile to 13-hydroxy lergotrile, a potent inhibitor of prolactin release in vitro.麦角腈代谢为13-羟基麦角腈，后者在体外是一种有效的催乳素释放抑制剂。
Biochem Pharmacol. 1978 May 1;27(9):1405-8. doi: 10.1016/0006-2952(78)90131-4.
9
The pathophysiology of hyperprolactinemic states and the role of newer ergot compounds in their treatment.高催乳素血症状态的病理生理学及新型麦角化合物在其治疗中的作用。
Fed Proc. 1978 Jun;37(8):2192-7.

普拉特链霉菌对麦角腈的N-去甲基化作用。

N-demethylation of lergotrile by Streptomyces platensis.

作者信息

Davis P J, Glade J C, Clark A M, Smith R V

出版信息

Appl Environ Microbiol. 1979 Nov;38(5):891-3. doi: 10.1128/aem.38.5.891-893.1979.

DOI:10.1128/aem.38.5.891-893.1979
PMID:44446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC243604/
Abstract

Thirty-eight microorganisms were screened for their ability to produce metabolites of the semisynthetic alkaloid, lergotrile. A total of five microorganisms were found to biotransform lergotrile, and N-desmethyl lergotrile was detected as the principal metabolite with most organisms. Streptomyces platensis (NRRL 2364) appeared to form the metabolite in highest yield, and a preparative-scale conversion was accomplished with a recovered yield of 50%. Structure proof was accomplished with comparative thin-layer chromatography, mixed melting point, mass spectrometry, and remethylation to lergotrile.

摘要

对38种微生物进行了筛选，以评估它们产生半合成生物碱麦角腈代谢物的能力。共发现5种微生物可生物转化麦角腈，大多数微生物产生的主要代谢物为N-去甲基麦角腈。普拉特链霉菌（NRRL 2364）似乎能以最高产量形成该代谢物，通过制备规模的转化获得了50%的回收率。通过比较薄层色谱、混合熔点、质谱分析以及将其重新甲基化生成麦角腈来完成结构鉴定。