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胚胎抗原与小鼠纤维肉瘤的生长

Embryonic antigens and growth of murine fibrosarcomata.

作者信息

Ménard S, Colnaghi M I, Della Porta G

出版信息

Br J Cancer. 1974 Dec;30(6):524-31. doi: 10.1038/bjc.1974.231.

DOI:10.1038/bjc.1974.231
PMID:4447783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009339/
Abstract

The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum. A direct relationship between amount of EA and tumour growing capacity was found. EA were detected also on fast dividing testicular cells. It is suggested that EA expression on tumour cells is related to a cell membrane function controlling mitosis rather than to a function specifically related to the neoplastic status. Tumour take of low doses of 2 EA-bearing sarcomata was found to be enhanced in anti-embryo immune BALB/c mice in comparison with that in normal and anti-fibroblast immune mice.

摘要

通过抗胚胎脾细胞的体外细胞介导细胞毒性以及抗胚胎抗血清的定量吸收，对13个BALB/c纤维肉瘤中的胚胎抗原（EA）量进行了估计。发现EA量与肿瘤生长能力之间存在直接关系。在快速分裂的睾丸细胞上也检测到了EA。有人提出，肿瘤细胞上EA的表达与控制有丝分裂的细胞膜功能有关，而不是与肿瘤状态特异性相关的功能有关。与正常和抗成纤维细胞免疫的小鼠相比，发现抗胚胎免疫的BALB/c小鼠中低剂量的2个携带EA的肉瘤的肿瘤接种率有所提高。

相似文献

1
Embryonic antigens and growth of murine fibrosarcomata.胚胎抗原与小鼠纤维肉瘤的生长
Br J Cancer. 1974 Dec;30(6):524-31. doi: 10.1038/bjc.1974.231.
2
Embryonic antigens shared between chemically induced lymphosarcomas and fibrosarcomas of the mouse.化学诱导的小鼠淋巴肉瘤和纤维肉瘤之间共有的胚胎抗原。
J Natl Cancer Inst. 1975 Feb;54(2):479-81.
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In vitro demonstration of tumor-specific common antigens and embryonal antigens in murine fibrosarcomas induced by 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽诱导的小鼠纤维肉瘤中肿瘤特异性共同抗原和胚胎抗原的体外证明
Cancer Res. 1973 Mar;33(3):478-81.
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The effects of tumor bearing upon changes in cell distribution and membrane antigen characteristics in murine spleen and thymus cell subpopulations.荷瘤对小鼠脾脏和胸腺细胞亚群中细胞分布及膜抗原特性变化的影响。
Cancer Res. 1973 Aug;33(8):1878-84.
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Natural anti-tumor serum reactivity in BALB/c mice. I. Characterization and interference with tumor growth.
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Suppressor cells in tumor-bearing mice capable of nonspecific blocking of in vitro immunization against transplant antigens.荷瘤小鼠体内能够非特异性阻断针对移植抗原的体外免疫的抑制细胞。
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本文引用的文献

1
Expression of H-2 and Moloney leukemia virus-determined cell-surface antigens in synchronized cultures of a mouse cell line.H-2和莫洛尼白血病病毒决定的细胞表面抗原在小鼠细胞系同步培养物中的表达。
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Effect of different sera on growth and "spontaneous" neoplastic transformation of mouse fibroblasts in vitro.
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Foetal antigens and cancer.胎儿抗原与癌症
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Immunogenic strength of sarcomas induced by methylcholanthrene in millipore filter diffusion chambers.甲基胆蒽在微孔滤膜扩散小室中诱导产生的肉瘤的免疫原性强度。
Cancer Res. 1973 Apr;33(4):750-4.
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In vitro demonstration of tumor-specific common antigens and embryonal antigens in murine fibrosarcomas induced by 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽诱导的小鼠纤维肉瘤中肿瘤特异性共同抗原和胚胎抗原的体外证明
Cancer Res. 1973 Mar;33(3):478-81.
8
Some similarities in the responses of mice to pregnancy and leukemogenesis.小鼠对怀孕和白血病发生的反应存在一些相似之处。
Int J Cancer. 1972 May 15;9(3):584-94. doi: 10.1002/ijc.2910090315.
9
A cross-reacting embryonic antigen in the membrane of rat sarcoma cells which is immunogenic in the syngeneic host.大鼠肉瘤细胞膜中的一种交叉反应性胚胎抗原，其在同基因宿主中具有免疫原性。
Br J Cancer. 1973 Jan;27(1):35-47. doi: 10.1038/bjc.1973.5.
10
Expression of membrane-bound IgM and HL-A antigens on lymphoblastoid cells in different stages of the cell cycle.膜结合IgM和HL-A抗原在细胞周期不同阶段的淋巴母细胞中的表达。
Eur J Immunol. 1974 May;4(5):327-32. doi: 10.1002/eji.1830040503.

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