McQueen D S
Br J Pharmacol. 1974 Apr;50(4):559-68. doi: 10.1111/j.1476-5381.1974.tb08589.x.
1 Some prostaglandins have been found to be capable of affecting respiration in anaesthetized cats.2 Prostaglandins E(1), E(2), F(2alpha), A(1) and A(2) all elicited increases in respiratory frequency when administered to cats anaesthetized with either pentobarbitone or alpha-chloralose. This effect was abolished by bilateral vagotomy.3 Prostaglandins of the E and A series, but not prostaglandin F(2alpha), elicited increases in tidal volume which were accompanied by falls in systemic blood pressure in cats anaesthetized with pentobarbitone. The changes in blood pressure were also obtained in cats anaesthetized with alpha-chloralose, but not the tidal volume changes.4 It is unlikely that the prostaglandins influenced respiration by direct actions on arterial chemoreceptors or baroreceptors.5 Mechanisms by which the prostaglandins may be acting to affect respiration are discussed.
已发现某些前列腺素能够影响麻醉猫的呼吸。
当用戊巴比妥或α-氯醛糖麻醉猫后，给予前列腺素E(1)、E(2)、F(2α)、A(1)和A(2)均会引起呼吸频率增加。双侧迷走神经切断术可消除这种效应。
E系列和A系列前列腺素，但不包括前列腺素F(2α)，在用戊巴比妥麻醉的猫中引起潮气量增加，同时伴有全身血压下降。在用α-氯醛糖麻醉的猫中也出现了血压变化，但潮气量没有变化。
前列腺素不太可能通过直接作用于动脉化学感受器或压力感受器来影响呼吸。
讨论了前列腺素可能影响呼吸的作用机制。
