缺血性肾脏释放肾素的机制。
The mechanism of renin release from the ischaemic kidney.
作者信息
Labal S E, Pola J L, Martinez Seeber A, Taquini A C
出版信息
Br J Pharmacol. 1974 Apr;50(4):601-2. doi: 10.1111/j.1476-5381.1974.tb08595.x.
The re-establishment of blood flow to an ischaemic kidney produced an elevation of blood pressure in the rat. This response did not occur in animals with a pithed spinal cord or in rats with low blood pressure produced by haemorrhage. When the blood pressure was raised in rats with pithed spinal cords, by the intravenous infusion of noradrenaline, the response was restored. Occlusion of the subclavian arteries did not prevent the response. It is considered that the increase in blood pressure, produced by renin release, after re-establishment of the blood flow in an ischaemic kidney is a 'washout' phenomenon independent of the integrity of the nervous system.
缺血性肾血流的重新建立会使大鼠血压升高。这种反应在脊髓毁损的动物或因出血导致低血压的大鼠中不会出现。当通过静脉输注去甲肾上腺素使脊髓毁损的大鼠血压升高时，该反应得以恢复。锁骨下动脉闭塞并不能阻止这种反应。据认为，缺血性肾血流重新建立后，由肾素释放引起的血压升高是一种与神经系统完整性无关的“洗脱”现象。
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