Lakova E
Eksp Med Morfol. 1980;19(2):71-5.
The objective of the present work was to study the changes in the brain and renal renin-angiotensin system (RAS) during their simultaneous stimulation by ischemia. Experiments were carried out on the following groups of male normotensive Wistar rats: intact, with brain ischemia, with renal ischemia, with combined brain and renal ischemia. The three ischemic groups of animals had some arterial pressure elevation without reaching hypertensive values. In animals with combined brain and renal ischemia brain renin concentration (BRC) was raised, while plasma renin activity (PRA) was reduced relative to the intact controls, i.e. as in animals with brain ischemia alone. Renal renin concentration (RRC) in the ischemic kidney was at the level of the one in intact animals and in animals with brain ischemia. In the intact contralateral kidney of rats with combined ischemia RRC was reduced relative to the intact kidney of animals with renal ischemia and statistically insignificantly reduced relative to the RRC in intact controls and in animals with brain ischemia. The results of this study showed that inverse ratio between renal and brain RAS exists also in the single clamped--birenal model of hypertension. Interaction between the two RAS is manifested when they both are simultaneously stimulated, with prevalence of the effect of brain RAS, which affects renin secretion in the kidney.
本研究的目的是探讨在缺血同时刺激大脑和肾脏肾素 - 血管紧张素系统（RAS）时其发生的变化。实验在以下几组雄性正常血压的Wistar大鼠上进行：完整组、大脑缺血组、肾脏缺血组、大脑和肾脏联合缺血组。三组缺血动物的动脉血压均有一定程度升高，但未达到高血压水平。在大脑和肾脏联合缺血的动物中，大脑肾素浓度（BRC）升高，而血浆肾素活性（PRA）相对于完整对照组降低，这与仅大脑缺血的动物情况相同。缺血肾脏中的肾素浓度（RRC）与完整动物及大脑缺血动物中的肾素浓度处于同一水平。在联合缺血大鼠的完整对侧肾脏中，RRC相对于肾脏缺血动物的完整肾脏降低，相对于完整对照组和大脑缺血动物的RRC降低，但差异无统计学意义。本研究结果表明，在单钳夹双肾高血压模型中，肾脏和大脑RAS之间也存在反比关系。当两个RAS同时受到刺激时，两者之间存在相互作用，其中大脑RAS的作用占主导，它会影响肾脏中的肾素分泌。
