潘生丁、己酮可可碱和利多氟嗪对兔十二指肠抑制过程的某些作用。
Some effects of dipyridamole, hexobendine and lidoflazine on inhibitory processes in rabbit duodenum.
作者信息
Hulme M E, Weston A H
出版信息
Br J Pharmacol. 1974 Apr;50(4):609-11. doi: 10.1111/j.1476-5381.1974.tb08598.x.
Abstract
Some of the effects of dipyridamole, hexobendine and lidoflazine on mechanical responses in rabbit duodenum have been investigated. In concentrations known to inhibit tissue accumulation of adenosine and its metabolites, none of these agents potentiated inhibitory responses to intramural nerve stimulation or to application of adenosine, adenosine triphosphate or phenylephrine. These results neither support nor dispute the suggestion that adenosine or a related nucleotide is the intramural inhibitory transmitter but do show that tissue accumulation in rabbit duodenum is not an important feature in the termination of the action of adenosine.
摘要
已对双嘧达莫、己酮可可碱和利多氟嗪对兔十二指肠机械反应的某些作用进行了研究。在已知能抑制腺苷及其代谢产物在组织中蓄积的浓度下，这些药物均未增强对壁内神经刺激或对应用腺苷、三磷酸腺苷或去氧肾上腺素的抑制反应。这些结果既不支持也不反驳腺苷或相关核苷酸是壁内抑制性递质这一观点，但确实表明兔十二指肠中的组织蓄积并非腺苷作用终止的重要特征。
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引用本文的文献
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Effects of some purine derivatives on the guinea-pig trachea and their interaction with drugs that block adenosine uptake.某些嘌呤衍生物对豚鼠气管的作用及其与阻断腺苷摄取药物的相互作用。
Br J Pharmacol. 1976 May;57(1):51-7. doi: 10.1111/j.1476-5381.1976.tb07655.x.
3
Dissimilarity between the responses to adenosine triphosphate or its related compounds and non-adrenergic inhibitory nerve stimulation in the longitudinal smooth muscle of pig stomach.猪胃纵行平滑肌对三磷酸腺苷或其相关化合物的反应与非肾上腺素能抑制性神经刺激反应之间的差异。
Br J Pharmacol. 1977 Jun;60(2):221-31. doi: 10.1111/j.1476-5381.1977.tb07744.x.
本文引用的文献
1
Potentiation of adenosine and the adenine nucleotides by dipyridamole.双嘧达莫对腺苷和腺嘌呤核苷酸的增强作用。
Br J Pharmacol Chemother. 1966 Nov;28(2):218-27. doi: 10.1111/j.1476-5381.1966.tb01888.x.
2
Nerve-mediated inhibition of mechanical activity in rabbit duodenum and the effects of desensitization to adenosine and several of its derivatives.神经介导的兔十二指肠机械活动抑制作用以及对腺苷及其几种衍生物脱敏的影响。
Br J Pharmacol. 1973 Jun;48(2):302-8. doi: 10.1111/j.1476-5381.1973.tb06916.x.
3
The accumulation of adenosine in rabbit intestinal muscle.腺苷在兔肠肌中的蓄积。
Br J Pharmacol. 1974 Apr;50(4):569-74. doi: 10.1111/j.1476-5381.1974.tb08590.x.
4
Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
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Noradrenaline storage particles in splenic nerve.脾神经中的去甲肾上腺素储存颗粒。
Philos Trans R Soc Lond B Biol Sci. 1971 Jun 17;261(839):313-7. doi: 10.1098/rstb.1971.0062.
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Potentiation of the effects of exogenously applied ATP and purinergic nerve stimulation on the guinea-pig taenia coli by dipyridamole and hexobendine.双嘧达莫和己酮可可碱对豚鼠结肠带中外源性应用ATP和嘌呤能神经刺激作用的增强
Eur J Pharmacol. 1972 Sep;19(3):343-50. doi: 10.1016/0014-2999(72)90100-8.
7
[3H]adenosine triphosphate: release during stimulation of enteric nerves.[3H]三磷酸腺苷：在刺激肠神经期间的释放
Science. 1971 Jul 23;173(3994):336-8. doi: 10.1126/science.173.3994.336.
8
Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut.有证据表明三磷酸腺苷或一种相关核苷酸是肠道中非肾上腺素能抑制性神经释放的递质物质。
Br J Pharmacol. 1970 Dec;40(4):668-88. doi: 10.1111/j.1476-5381.1970.tb10646.x.
9
The nervous release and the action of substances which affect intestinal muscle through neither adrenoreceptors nor cholinoreceptors.神经释放以及通过既非肾上腺素能受体也非胆碱能受体来影响肠肌的物质的作用。
Philos Trans R Soc Lond B Biol Sci. 1973 Mar 15;265(867):123-33. doi: 10.1098/rstb.1973.0015.
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