某些嘌呤衍生物对豚鼠气管的作用及其与阻断腺苷摄取药物的相互作用。
Effects of some purine derivatives on the guinea-pig trachea and their interaction with drugs that block adenosine uptake.
作者信息
Coleman R A
出版信息
Br J Pharmacol. 1976 May;57(1):51-7. doi: 10.1111/j.1476-5381.1976.tb07655.x.
1 Adenosine, adenosine 5'-triphosphate (ATP), adenine, inosine and guanosine all caused concentration-dependent relaxations of guinea-pig tracheal smooth muscle in vitro. The relative potencies in descending order were: adenine greater than or equal to guanosine greater than inosine greater than or equal to adenosine greater than or equal to ATP. 2 Responses to the purine compounds were unaffected by propranolol (1 mug/ml). 3 The spasmolytic potencies of adenosine and ATP were greatly enhanced in the presence of the adenosine uptake blocking drugs dipyridamole, hexobendine or Dilazep, whereas responses to adenine were unaffected and those to inosine and guanosine were reduced. 4 The spasmolytic potencies of noradrenaline, aminophylline, prostaglandin E2 and glyceryl trinitrate were unaffected by dipyridamole, hexobendine and Dilazep. 5 It is suggested that an adenosine uptake process may exist in the trachea of the guinea-pig and that this process is inhibited by dipyridamole, hexobendine and Dilazep.
1 腺苷、5'-三磷酸腺苷（ATP）、腺嘌呤、肌苷和鸟苷在体外均能引起豚鼠气管平滑肌浓度依赖性舒张。相对效力从高到低依次为：腺嘌呤≥鸟苷＞肌苷≥腺苷≥ATP。2 对嘌呤化合物的反应不受普萘洛尔（1微克/毫升）影响。3 在存在腺苷摄取阻断药物双嘧达莫、己酮可可碱或地拉卓的情况下，腺苷和ATP的解痉效力大大增强，而对腺嘌呤的反应不受影响，对肌苷和鸟苷的反应则减弱。4 去甲肾上腺素、氨茶碱、前列腺素E2和硝酸甘油的解痉效力不受双嘧达莫、己酮可可碱和地拉卓影响。5 提示豚鼠气管中可能存在腺苷摄取过程，且该过程受双嘧达莫、己酮可可碱和地拉卓抑制。
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