神经介导的兔十二指肠机械活动抑制作用以及对腺苷及其几种衍生物脱敏的影响。
Nerve-mediated inhibition of mechanical activity in rabbit duodenum and the effects of desensitization to adenosine and several of its derivatives.
作者信息
Weston A H
出版信息
Br J Pharmacol. 1973 Jun;48(2):302-8. doi: 10.1111/j.1476-5381.1973.tb06916.x.
Abstract
- Inhibition of mechanical activity in longitudinal muscle strips of rabbit duodenum was induced by perivascular and intramural nerve stimulation.2. The effects of perivascular stimulation were abolished by phentolamine + propranolol, guanethidine, reserpine and by tetrodotoxin. The effects of intramural stimulation were abolished only by tetrodotoxin.3. Noradrenaline, phenylephrine, isoprenaline, adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and adenosine each produced an inhibition of mechanical activity. The relative potencies of these agonists were noradrenaline>isoprenaline>phenylephrine>ATP>ADP>adenosine>AMP.4. Exposure of tissues to high concentrations of either ATP or adenosine desensitized the tissue to further exposure to ATP, ADP, AMP and adenosine, whilst the inhibitory effects of noradrenaline, phenylephrine and isoprenaline and of perivascular and intramural stimulation were unaffected. The effects of desensitization were reversible.5. It was concluded that the effects of intramural stimulation were mediated neither by noradrenaline nor by adenosine or its derivatives.
摘要
血管周围和壁内神经刺激可诱导家兔十二指肠纵行肌条机械活动的抑制。
酚妥拉明+普萘洛尔、胍乙啶、利血平和河豚毒素可消除血管周围刺激的作用。壁内刺激的作用仅被河豚毒素消除。
去甲肾上腺素、去氧肾上腺素、异丙肾上腺素、三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）和腺苷均可抑制机械活动。这些激动剂的相对效力为去甲肾上腺素>异丙肾上腺素>去氧肾上腺素>ATP>ADP>腺苷>AMP。
将组织暴露于高浓度的ATP或腺苷会使组织对进一步暴露于ATP、ADP、AMP和腺苷产生脱敏作用，而去甲肾上腺素、去氧肾上腺素和异丙肾上腺素以及血管周围和壁内刺激的抑制作用不受影响。脱敏作用是可逆的。
得出的结论是，壁内刺激的作用既不是由去甲肾上腺素介导的，也不是由腺苷或其衍生物介导的。
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Inhibition of the longitudinal muscle of rabbit duodenum.兔十二指肠纵肌的抑制作用。
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