脑自动调节功能衰竭作为老年人脑功能障碍的一个原因。
Failure of cerebral autoregulation as a cause of brain dysfunction in the elderly.
作者信息
Wollner L, McCarthy S T, Soper N D, Macy D J
出版信息
Br Med J. 1979 Apr 28;1(6171):1117-8. doi: 10.1136/bmj.1.6171.1117.
Abstract
Cerebral blood flow in relation to change in arterial pressure was measured in 11 elderly patients with postural hypotension. Seven patients with symptoms showed bilateral or unilateral failure of cerebral autoregulation, while the four asymptomatic patients did not. Variations in cerebral autoregulation would explain why some elderly people with minor falls of systemic arterial pressure develop clinical signs of cerebral ischaemia whereas others with greater falls in blood pressure remain asymptomatic. Elderly patients with impaired autoregulation may be at risk of brain damage from minor falls in blood pressure.
摘要
对11例体位性低血压老年患者测量了脑血流量与动脉压变化的关系。7例有症状的患者出现双侧或单侧脑自动调节功能衰竭，而4例无症状患者未出现。脑自动调节功能的变化可以解释为什么一些全身动脉压轻度下降的老年人会出现脑缺血的临床体征，而另一些血压下降幅度更大的老年人却没有症状。脑自动调节功能受损的老年患者可能因血压轻度下降而有脑损伤的风险。
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