Meyers W M, Shelly W M, Connor D H
Am J Trop Med Hyg. 1974 Sep;23(5):924-9. doi: 10.4269/ajtmh.1974.23.924.
Eight patients from Zaire with Mycobacterium ulcerans infection were treated by the local application of heat to maintain a temperature of approximately 40 degrees C in the ulcerated area. All lesions healed without surgical intervention and without local recurrences during follow-up periods of up to 22 months. This study shows that local heat promotes healing of M. ulcerans lesions. We postulate that the mechanism is primarily by direct inhibition of multiplication of M. ulcerans. Other possible contributory effects are discussed.
来自扎伊尔的8名溃疡分枝杆菌感染患者接受了局部加热治疗，以使溃疡部位的温度维持在约40摄氏度。在长达22个月的随访期内，所有病灶均愈合，无需手术干预，也无局部复发。本研究表明，局部加热可促进溃疡分枝杆菌病灶的愈合。我们推测其机制主要是直接抑制溃疡分枝杆菌的繁殖。还讨论了其他可能的促成作用。
