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The increased rate of ethanol removal from blood of clofibrate-treated rats.氯贝丁酯处理的大鼠从血液中清除乙醇的速率增加。
Biochem J. 1974 Apr;140(1):117-20. doi: 10.1042/bj1400117.
2
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3
The effect of ethyl-alpha-p-chlorophenoxisobutyrate (clofibrate) on alcohol metabolism.
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4
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Acta Pharmacol Toxicol (Copenh). 1976 Sep;39(3):365-73. doi: 10.1111/j.1600-0773.1976.tb03187.x.
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[Effect of ethanol and clofibrate on the activity of lipid catabolism enzyme systems in rat liver].[乙醇和氯贝丁酯对大鼠肝脏脂质分解酶系统活性的影响]
Farmakol Toksikol. 1983 Sep-Oct;46(5):86-90.
6
Effect of clofibrate on fatty acid desaturation of rats treated with ethanol.氯贝丁酯对乙醇处理大鼠脂肪酸去饱和作用的影响。
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7
Action of tiadenol and clofibrate on biliary excretions of cholesterol and bile salts in rats.
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8
Effect of clofibrate on DNA synthesis in rat liver and kidney.
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Synergism of ethanol and clofibrate in the lauric acid hydroxylation.乙醇与氯贝丁酯在月桂酸羟基化反应中的协同作用。
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[Effect of lipid normalizers (clofibrate and procetofene) on chylomicron metabolism in rats].[脂质调节剂（氯贝丁酯和普罗考芬）对大鼠乳糜微粒代谢的影响]
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The peroxisome proliferator-activated receptor alpha agonist fenofibrate attenuates alcohol self-administration in rats.过氧化物酶体增殖物激活受体α激动剂非诺贝特可减少大鼠的酒精自我给药。
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Clofibrate-induced increase in coenzyme A concentration in rat tissues.氯贝丁酯诱导大鼠组织中辅酶A浓度升高。
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本文引用的文献

1
Ethyl alcohol metabolism in animal tissues.动物组织中的乙醇代谢
Biochem J. 1938 Feb;32(2):299-307. doi: 10.1042/bj0320299.
2
Evaluation of tri-iodothyronine in the treatment of acute alcoholic intoxication.
N Engl J Med. 1962 Jul 5;267:1-6. doi: 10.1056/NEJM196207052670101.
3
INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT.甲状腺激素对大鼠各器官中L-α-甘油磷酸脱氢酶及其他脱氢酶的影响
J Biol Chem. 1965 Mar;240:1427-36.
4
[An enzymatic microdetermination method for ammonia, specifically for extracts of animal tissues and fluids. Determination of NH4 ions in blood].[一种用于氨的酶促微量测定方法，特别适用于动物组织和体液的提取物。血液中NH4离子的测定]
Biochem Z. 1963;337:312-9.
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Determination of citrate with citrate lyase.用柠檬酸裂解酶测定柠檬酸。
Anal Biochem. 1966 Dec;17(3):369-76. doi: 10.1016/0003-2697(66)90172-2.
6
Nature of the hepatomegalic effect produced by ethyl-chlorophenoxy-isobutyrate in the rat.氯苯丁酯在大鼠体内产生肝肿大效应的性质。
Nature. 1965 Nov 27;208(5013):856-8. doi: 10.1038/208856a0.
7
The effects of p-chlorophenoxyisobutyrate on the turnover rate and distribution of thyroid hormone in the rat.对氯苯氧异丁酸对大鼠甲状腺激素周转率和分布的影响。
Biochem Pharmacol. 1969 Mar;18(3):613-24. doi: 10.1016/0006-2952(69)90086-0.
8
Influence of thyroxine on the metabolism of ethanol and glycerol in rat liver slices.甲状腺素对大鼠肝切片中乙醇和甘油代谢的影响。
Eur J Biochem. 1968 Jun;5(1):13-7. doi: 10.1111/j.1432-1033.1968.tb00329.x.
9
Ethanol metabolism in rats treated with ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate).用乙基-α-对氯苯氧异丁酸酯（氯贝丁酯）处理的大鼠的乙醇代谢
Life Sci II. 1971 Jun 22;10(12):661-70. doi: 10.1016/0024-3205(71)90148-2.
10
The physiological role of liver alcohol dehydrogenase.肝脏乙醇脱氢酶的生理作用。
Biochem J. 1970 Jul;118(4):635-44. doi: 10.1042/bj1180635.

氯贝丁酯处理的大鼠从血液中清除乙醇的速率增加。

The increased rate of ethanol removal from blood of clofibrate-treated rats.

作者信息

Hawkins R A, Nielsen R C, Veech R L

出版信息

Biochem J. 1974 Apr;140(1):117-20. doi: 10.1042/bj1400117.

DOI:10.1042/bj1400117
PMID:4451550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1167979/
Abstract

After ethanol injection similar metabolite changes were found in livers of clofibrate-treated and non-treated rats. The rate of ethanol removal from blood of clofibrate-treated rats was increased by 50%, but this was directly proportional to the increased liver size caused by clofibrate. No other difference needs to be postulated to explain the increased rate of ethanol removal from blood.

摘要

乙醇注射后，在氯贝丁酯治疗组和未治疗组大鼠的肝脏中发现了类似的代谢物变化。氯贝丁酯治疗组大鼠血液中乙醇的清除率提高了50%，但这与氯贝丁酯导致的肝脏增大直接相关。无需假定其他差异来解释血液中乙醇清除率的提高。