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The mechanism of microsomal hydroxylation of 7-methylbenz(a)-anthracene and 7,12-dimethylbenz(a)anthracene by oxygen-18 studies.

作者信息

Grandjean C, Cavalieri E

出版信息

Biochem Biophys Res Commun. 1974 Dec 11;61(3):912-9. doi: 10.1016/0006-291x(74)90242-3.

DOI:10.1016/0006-291x(74)90242-3
PMID:4451566
Abstract
摘要

相似文献

1
The mechanism of microsomal hydroxylation of 7-methylbenz(a)-anthracene and 7,12-dimethylbenz(a)anthracene by oxygen-18 studies.通过氧-18研究7-甲基苯并(a)蒽和7,12-二甲基苯并(a)蒽微粒体羟基化的机制。
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2
In vitro metabolism of 12-methylbenz(A)anthracene: effect of the methyl group on the stereochemistry of a 5,6-dihydrodiol metabolite.12-甲基苯并(A)蒽的体外代谢:甲基对一种5,6-二氢二醇代谢物立体化学的影响。
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3
Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic microsomes.7,12-二甲基苯并[a]蒽在肝微粒体中的代谢途径。
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4
The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.
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5
Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.芳香多环烃的环氧衍生物。与7,12-二甲基苯并(a)蒽相关的环氧化物的制备与代谢。
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6
Comparative biologic activities of 7,12-dimethylbenz(a)anthracene, 7-hydroxymethyl-12-methylbenz(a)anthracene, 7,12-dehydroxy-methylbenz(a)anthracene, and 4-methoxy-7,12-dimethylbenz(a)anthracene in the Sprague-Dawley female rat.7,12-二甲基苯并(a)蒽、7-羟甲基-12-甲基苯并(a)蒽、7,12-去羟基甲基苯并(a)蒽和4-甲氧基-7,12-二甲基苯并(a)蒽在斯普拉格-道利雌性大鼠中的比较生物学活性
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7
The formation of an epoxide in the microsomal metabolism of 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽微粒体代谢过程中环氧物的形成。
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8
Metabolism of 7,12-dimethylbenz(a)anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene by rat liver and microsomes.大鼠肝脏及微粒体对7,12-二甲基苯并(a)蒽和7-羟甲基-12-甲基苯并(a)蒽的代谢
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Differences between products of binding of 7,12-dimethylbenz[a]anthracene to DNA in mouse skin and in a rat liver microsomal system.
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10
Identification of 8, 9-dihydro-8, 9-dihydroxy-7, 12-dimethylbenz(a)anthracene as a rat liver metabolite of 7, 12-dimethylbenz(a) anthracene.
Biochem Pharmacol. 1976 Aug 15;25(16):1927-30. doi: 10.1016/0006-2952(76)90204-5.