大鼠乳汁中的致癌物。哺乳期大鼠将摄入的二乙基亚硝胺转移至乳汁中。
Carcinogens in rat milk. Transfer of ingested diethylnitrosamine into milk by lactating rats.
作者信息
Schoental R, Gough T A, Webb K S
出版信息
Br J Cancer. 1974 Sep;30(3):238-40. doi: 10.1038/bjc.1974.187.
Abstract
Mothers of 5-day old rats were given diethylnitrosamine (DEN) (130 mg/kg body weight) by stomach tube. The milk removed from the stomachs of the suckling young contained 5, 16 and 36 parts/10(6) of DEN at 2, 4 and 6 hours respectively after they started suckling the treated mothers. After 49 hours, DEN was no more detectable in the milk.
摘要
给5日龄大鼠的母亲通过胃管给予二乙基亚硝胺（DEN）（130毫克/千克体重）。在幼崽开始吸食经处理的母鼠乳汁后2小时、4小时和6小时，从哺乳幼崽胃中吸出的乳汁中分别含有5、16和36 ppm的DEN。49小时后，乳汁中不再能检测到DEN。
相似文献
1
Carcinogens in rat milk. Transfer of ingested diethylnitrosamine into milk by lactating rats.大鼠乳汁中的致癌物。哺乳期大鼠将摄入的二乙基亚硝胺转移至乳汁中。
Br J Cancer. 1974 Sep;30(3):238-40. doi: 10.1038/bjc.1974.187.
2
Occurrence of diethylnitrosamine in some samples of food.某些食品样本中存在二乙基亚硝胺。
Food Cosmet Toxicol. 1968 Oct;6(3):341-8. doi: 10.1016/s0015-6264(68)80005-7.
3
Transfer of the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene into the milk of lactating rats.烟草特异性致癌物N'-亚硝基降烟碱、4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁酮和苯并[a]芘向哺乳期大鼠乳汁中的转移。
Carcinogenesis. 1987 Mar;8(3):433-7. doi: 10.1093/carcin/8.3.433.
4
Milk as transport agent for diethylnitrosamine in Syrian golden hamsters.牛奶作为二乙基亚硝胺在叙利亚金仓鼠体内的转运介质
J Natl Cancer Inst. 1974 Jul;53(1):281-2. doi: 10.1093/jnci/53.1.281.
5
The development of tumours in a female rat and her offspring, following administration of diethylnitrosamine to the mother during nursing.在哺乳期给母鼠施用二乙基亚硝胺后，雌性大鼠及其后代肿瘤的发生情况。
Br J Cancer. 1973 Jul;28(1):84. doi: 10.1038/bjc.1973.100.
6
Salivary levels of N-nitrosamines and some metabolites after IP injection of N-nitrosamines in rats.
Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):283-91.
7
Methods for the estimation of the excretion of proxicromil and its metabolites in the milk of nursing rat mothers.测定哺乳期大鼠母亲乳汁中丙卡特罗及其代谢物排泄量的方法。
Xenobiotica. 1981 Dec;11(12):871-7. doi: 10.3109/00498258109045325.
8
Induction of peroxisomal enzymes in livers of neonatal rats exposed to lactating mothers treated with hypolipidaemic drugs. Role of drug metabolite transfer in milk.用降血脂药物治疗的哺乳期母鼠所哺育的新生大鼠肝脏中过氧化物酶体酶的诱导。药物代谢产物在乳汁中的转移作用。
Biochem J. 1983 Mar 15;210(3):875-83. doi: 10.1042/bj2100875.
9
Contamination of some fermented Nigerian beverages by carcinogenic nitrosamines.
Trop Geogr Med. 1979 Jun;31(2):283-90.
10
Metabolism of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by lactating Fischer 344 rats and their nursing pups.哺乳期Fischer 344大鼠及其哺乳幼崽对食物源性致癌物2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶的代谢
J Natl Cancer Inst. 1994 Jul 20;86(14):1065-70. doi: 10.1093/jnci/86.14.1065.
引用本文的文献
1
Risk assessment of nitrosamines in food.食品中亚硝胺的风险评估。
EFSA J. 2023 Mar 28;21(3):e07884. doi: 10.2903/j.efsa.2023.7884. eCollection 2023 Mar.
本文引用的文献
1
Occurrence of diethylnitrosamine in some samples of food.某些食品样本中存在二乙基亚硝胺。
Food Cosmet Toxicol. 1968 Oct;6(3):341-8. doi: 10.1016/s0015-6264(68)80005-7.
2
Gas chromatographic determination and mass spectrometric confirmation of N-nitrosodimethylamine in smoke-processed marine fish.
J Agric Food Chem. 1971 Mar-Apr;19(2):250-3. doi: 10.1021/jf60174a003.
3
Toxicity of nitrosamines: their possible human health hazards.亚硝胺的毒性：它们对人类健康可能造成的危害。
Food Cosmet Toxicol. 1971 Apr;9(2):207-18. doi: 10.1016/0015-6264(71)90306-3.
4
Carcinogenic nitroso compounds.致癌亚硝基化合物。
Adv Cancer Res. 1967;10:163-246. doi: 10.1016/s0065-230x(08)60079-2.
5
The development of tumours in a female rat and her offspring, following administration of diethylnitrosamine to the mother during nursing.在哺乳期给母鼠施用二乙基亚硝胺后，雌性大鼠及其后代肿瘤的发生情况。
Br J Cancer. 1973 Jul;28(1):84. doi: 10.1038/bjc.1973.100.
6
A method for the detection of traces of nitrosamines using combined gas chromatography and mass spectrometry.一种使用气相色谱和质谱联用技术检测痕量亚硝胺的方法。
J Chromatogr. 1973 May 16;79:57-63. doi: 10.1016/s0021-9673(01)85273-0.
7
Examination of nonfat dry milk for the presence of nitrosamines.检测脱脂奶粉中是否存在亚硝胺。
J Dairy Sci. 1972 Nov;55(11):1574-6. doi: 10.3168/jds.S0022-0302(72)85723-0.
8
EWstimation of steam-volatile N-nitrosamines in foods at the 1 micro g-kg level.食品中1微克/千克水平蒸汽挥发性N-亚硝胺的估算。
Nature. 1972 Aug 11;238(5363):342-3. doi: 10.1038/238342a0.
9
[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):3-5. doi: 10.1007/BF00284333.
10
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].[65种不同N-亚硝基化合物对BD大鼠的器官特异性致癌作用]
Z Krebsforsch. 1967;69(2):103-201.
Zotero 插件