利用正常小鼠、震颤小鼠和营养不良小鼠研究体外雪旺细胞迁移与损伤的关系。

The relationship of Schwann cell migration in vitro to injury, using normal, Wobbler, and dystrophic mice.

作者信息

Lewkowicz S J

出版信息

Brain Res. 1979 Jun 29;169(3):443-54. doi: 10.1016/0006-8993(79)90396-2.

Abstract

A quantitative in vitro study of the cellular outgrowth from mouse sciatic nerve explants has been carried out using both normal untreated nerves and nerves taken at various times after the in vivo application of trauma. The results obtained have been compared with the results for outgrowth from sciatic nerve of two neurological mutants: 'the Wobbler mouse' and the 'ReJ 129 Dystrophic mouse'. It has been shown that the in vitro response to peripheral injury does reflect the activity known to occur in vivo. Outgrowth from explants of mutant mouse nerves, although differing from normal has been found to be less profuse than that occurring after mechanical nerve injury.

摘要

利用正常未处理的神经以及在体内施加创伤后不同时间获取的神经，对小鼠坐骨神经外植体的细胞生长进行了定量体外研究。将所得结果与两种神经学突变体“摇摆小鼠”和“ReJ 129营养不良小鼠”的坐骨神经生长结果进行了比较。结果表明，体外对周围神经损伤的反应确实反映了体内已知发生的活动。尽管突变小鼠神经外植体的生长与正常情况不同，但已发现其生长不如机械性神经损伤后旺盛。