冠状动脉制剂中外神经元摄取抑制剂对去甲肾上腺素反应的敏化作用。
Sensitization of noradrenaline responses by inhibitors of extraneuronal uptake in a coronary artery preparation.
作者信息
Kalsner S
出版信息
Br J Pharmacol. 1974 Jul;51(3):453-55. doi: 10.1111/j.1476-5381.1974.tb10682.x.
Abstract
Inhibition of neuronal uptake with cocaine had no significant effect on the dose-response curve to noradrenaline in strips of beef coronary artery. However, responses were enhanced about 3-fold by 17beta-oestradiol and the haloalkylamine GD-131, two known inhibitors of extraneuronal uptake.
摘要
可卡因对神经元摄取的抑制作用，对牛肉冠状动脉条带中去甲肾上腺素的剂量反应曲线没有显著影响。然而，17β-雌二醇和卤代烷基胺GD-131（两种已知的非神经元摄取抑制剂）可使反应增强约3倍。
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本文引用的文献
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Br J Pharmacol. 1969 Mar;35(3):440-55. doi: 10.1111/j.1476-5381.1969.tb08285.x.
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Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta.氢化可的松增强兔主动脉对肾上腺素和去甲肾上腺素反应的机制
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