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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Brine F, Cornish E J, Miller R C

Br J Pharmacol. 1979 Dec;67(4):553-61. doi: 10.1111/j.1476-5381.1979.tb08701.x.

Transmural stimulation of intrinsic sympathetic nerves and exogenous catecholamines produce beta 1-adrenoceptor mediated relaxant responses in strips of contracted sheep coronary artery. 2. The neuronal uptake inhibitors, metaraminol, cocaine and desipramine and the extraneuronal uptake inhibitor, cortisol, failed to potentiate responses to noradrenaline or sympathetic stimulation; responses to isoprenaline were enhanced by cortisol. 3. Oxytetracycline, which inhibits binding to connective tissue fibres, did not affect responses to noradrenaline or nerve stimulation. 4. 17 beta-Oestradiol, caffeine and U0521 proved to be unsuitable compounds for studying catecholamine inactivation since they non-selectively potentiated responses to noradrenaline and isoprenaline. 5. It is concluded that catecholamine inactivation processes do not modify transmitter function in sheep coronary arteries.

对绵羊冠状动脉条带进行跨壁刺激内源性交感神经和外源性儿茶酚胺，可产生β1-肾上腺素能受体介导的舒张反应。2. 神经元摄取抑制剂间羟胺、可卡因和地昔帕明以及非神经元摄取抑制剂皮质醇，均未能增强对去甲肾上腺素或交感神经刺激的反应；皮质醇增强了对异丙肾上腺素的反应。3. 抑制与结缔组织纤维结合的土霉素，不影响对去甲肾上腺素或神经刺激的反应。4. 17β-雌二醇、咖啡因和U0521被证明是不适合用于研究儿茶酚胺失活的化合物，因为它们非选择性地增强了对去甲肾上腺素和异丙肾上腺素的反应。5. 得出的结论是，儿茶酚胺失活过程不会改变绵羊冠状动脉中的递质功能。

Brine F, Cornish E J, Miller R C

Br J Pharmacol. 1979 Dec;67(4):553-61. doi: 10.1111/j.1476-5381.1979.tb08701.x.

Transmural stimulation of intrinsic sympathetic nerves and exogenous catecholamines produce beta 1-adrenoceptor mediated relaxant responses in strips of contracted sheep coronary artery. 2. The neuronal uptake inhibitors, metaraminol, cocaine and desipramine and the extraneuronal uptake inhibitor, cortisol, failed to potentiate responses to noradrenaline or sympathetic stimulation; responses to isoprenaline were enhanced by cortisol. 3. Oxytetracycline, which inhibits binding to connective tissue fibres, did not affect responses to noradrenaline or nerve stimulation. 4. 17 beta-Oestradiol, caffeine and U0521 proved to be unsuitable compounds for studying catecholamine inactivation since they non-selectively potentiated responses to noradrenaline and isoprenaline. 5. It is concluded that catecholamine inactivation processes do not modify transmitter function in sheep coronary arteries.

对绵羊冠状动脉条带进行跨壁刺激内源性交感神经和外源性儿茶酚胺，可产生β1-肾上腺素能受体介导的舒张反应。2. 神经元摄取抑制剂间羟胺、可卡因和地昔帕明以及非神经元摄取抑制剂皮质醇，均未能增强对去甲肾上腺素或交感神经刺激的反应；皮质醇增强了对异丙肾上腺素的反应。3. 抑制与结缔组织纤维结合的土霉素，不影响对去甲肾上腺素或神经刺激的反应。4. 17β-雌二醇、咖啡因和U0521被证明是不适合用于研究儿茶酚胺失活的化合物，因为它们非选择性地增强了对去甲肾上腺素和异丙肾上腺素的反应。5. 得出的结论是，儿茶酚胺失活过程不会改变绵羊冠状动脉中的递质功能。