豚鼠实验性肺栓塞的肺力学效应及其支气管扩张药物对其的影响
Pulmonary mechanical effects of experimental lung embolism and their modification by bronchodilator drugs in the guinea-pig.
作者信息
Daly M J
出版信息
Br J Pharmacol. 1974 Aug;51(4):599-601. doi: 10.1111/j.1476-5381.1974.tb09679.x.
Abstract
In the anaesthetized guinea-pig micro-embolism induced by barium sulphate causes marked increases in pulmonary resistance and decreases in pulmonary compliance. Bronchodilator drugs prevent these changes with salbutamol showing much greater activity on pulmonary resistance changes than compliance changes. The results are discussed with regard to the site of action in the respiratory tree and potential clinical use.
摘要
在麻醉的豚鼠中，硫酸钡诱导的微栓塞会导致肺阻力显著增加，肺顺应性降低。支气管扩张药可预防这些变化，其中沙丁胺醇对肺阻力变化的作用比对顺应性变化的作用大得多。本文就其在呼吸树中的作用部位及潜在临床应用进行了讨论。
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本文引用的文献
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2
LOCATION AND MECHANISM OF AIRWAY CONSTRICTION AFTER BARIUM SULFATE MICROEMBOLISM.硫酸钡微栓塞后气道收缩的部位及机制
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Ventilatory responses to embolization of lung.对肺栓塞的通气反应。
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Pulmonary embolism.肺栓塞
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