Okulov V B, Anisimov V N, Chepik O F, Azarova M A
Biull Eksp Biol Med. 1980 Mar;89(3):335-7.
Tumors of the cervicovaginal epithelium were induced in BALB/c female mice with local application of dimethylbenzanthra cene. In the course of inducing tumors or after their appearance the mice were treated intravaginally with 55-81% ethanolic extract of the rat skin or liver (control) containing 1% chalones. The skin extract rather than liver one delays slightly the growth and incidence of cervical and vaginal tumours, and increases the survival of animals.
通过局部应用二甲基苯并蒽在BALB/c雌性小鼠中诱发宫颈阴道上皮肿瘤。在诱发肿瘤过程中或肿瘤出现后，给小鼠阴道内施用含1%抑素的大鼠皮肤或肝脏的55 - 81%乙醇提取物（作为对照）。皮肤提取物而非肝脏提取物能略微延缓宫颈和阴道肿瘤的生长及发生率，并提高动物的存活率。
