某些降压药物对下丘脑刺激效应的影响。

Influence of some hypotensive drugs on the effects of hypothalamic stimulation.

作者信息

van Bogaert A, de Schepper J

出版信息

Cardiology. 1979;64(3):162-9. doi: 10.1159/000170613.

Abstract

Clonidine, L-alpha-methyldopa, propranolol as well as noradrenaline, when injected directly into the hypothalamic paraventricular (PV) nucleus area, enhance the activity of this center. Lidoflazine appears to be inactive. Since the electrical, chemical and pharmacological stimulation of the PV area elicits the same depressor cardiovascular reactions, a specific differentiation of this nucleus as a depressor center is proposed. The above-mentioned drugs, when introduced into the ventromedial nucleus area, enhance the pressor effects produced by stimulation of this nucleus. Thus, the hypothalamic depressor activity is not linked with an inhibition of the ventromedial pressor activity.

摘要

可乐定、L-α-甲基多巴、普萘洛尔以及去甲肾上腺素直接注入下丘脑室旁（PV）核区域时，会增强该中枢的活动。利多氟嗪似乎无此作用。由于对PV区域进行电刺激、化学刺激和药理刺激会引发相同的降压心血管反应，因此提出将该核区明确为降压中枢。上述药物注入腹内侧核区域时，会增强刺激该核所产生的升压效应。因此，下丘脑的降压活动与腹内侧升压活动的抑制并无关联。