药物对汞诱导的大鼠足爪水肿的影响。
Effect of drugs on rat paw oedema induced by mercury.
作者信息
Jindal M N, Kelkar V V, Vaishnav U H
出版信息
Br J Pharmacol. 1974 Dec;52(4):609-12. doi: 10.1111/j.1476-5381.1974.tb09731.x.
1 Metallic mercury (0.04 ml) injected into the foot pad of rats induced a consistent inflammatory reaction, which at 4 h showed oedema but no cellular infiltration or vascular changes. The lesions exhibited lymphocytic infiltration, vasodilatation and haemorrhages at 24 and 48 h, and often became cystic after 2-3 weeks, before healing. The oedema volume at 4 h was used to test anti-inflammatory activity of drugs.2 Cortisone, phenylbutazone, indomethacin, acetylsalicylic acid, flufenamic acid and propranolol exhibited potent, dose-related anti-inflammatory activity. Aminopyrine, chloroquine and chlorpromazine were only moderately effective. Dimercaprol, adrenaline, and to some extent, mepyramine also inhibited mercury-induced oedema.3 This simple model of acute inflammation may be useful for preliminary tests of anti-inflammatory activity.
向大鼠足垫注射0.04毫升金属汞会引发持续的炎症反应，4小时时出现水肿，但无细胞浸润或血管变化。损伤在24小时和48小时时表现为淋巴细胞浸润、血管扩张和出血，在愈合前2 - 3周常形成囊肿。4小时时的水肿体积用于测试药物的抗炎活性。
可的松、保泰松、吲哚美辛、乙酰水杨酸、氟芬那酸和普萘洛尔表现出强效的、剂量相关的抗炎活性。氨基比林、氯喹和氯丙嗪效果一般。二巯丙醇、肾上腺素以及在一定程度上的甲氧苄二胺也能抑制汞诱导的水肿。
这个简单的急性炎症模型可能有助于抗炎活性的初步测试。
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