Steinberg D M, Allan R N, Thompson H, Brooke B N, Alexander-Williams J, Cooke W T
Gut. 1974 Nov;15(11):845-51. doi: 10.1136/gut.15.11.845.
This paper reports the indications for, and results of, excision of the large intestine with ileostomy in 73 patients with Crohn's colitis who have been followed for a mean of nine years since resection. Sixty-four of them are still alive and all but two of the survivors are now in good health.However, 23 (33%) have developed recurrent Crohn's disease since resection. This is higher than that reported in many other series and may be due to differences in the length of follow up, the site and extent of colonic disease, the age of the patient at the time of excision with ileostomy, and differences in the pathological interpretation of the diagnosis of Crohn's disease. The high recurrence rate in this series lends caution to the view that the prognosis after excisional surgery and ileostomy for Crohn's colitis is as good as after the same operation for ulcerative colitis and should influence the decision when the alternative of medical or surgical management are being considered for patients with Crohn's colitis.
本文报告了73例克罗恩病性结肠炎患者行大肠切除并回肠造口术的适应证及结果,这些患者自切除术后平均随访了9年。其中64例仍存活,除2例幸存者外,其余均健康状况良好。然而,23例(33%)自切除术后出现了克罗恩病复发。这一比例高于许多其他系列报道,可能是由于随访时间长短、结肠疾病的部位和范围、回肠造口术切除时患者的年龄以及对克罗恩病诊断的病理解释存在差异。本系列中的高复发率提醒人们,对于克罗恩病性结肠炎,切除手术及回肠造口术后的预后并不像溃疡性结肠炎行相同手术后那样良好,这在考虑对克罗恩病性结肠炎患者采用药物或手术治疗方案时应影响决策。