Cooper J C, Jones D, Williams N S
Ann R Coll Surg Engl. 1986 Sep;68(5):279-82.
The outcome of 42 patients undergoing colectomy and ileorectal anastomosis (IRA) for Crohn's colitis, which largely spared the rectum, was studied. Operative mortality was 7% (3 patients) and each patient died as a result of anastomotic breakdown. The overall incidence of anastomotic breakdown was 16.7% (7 patients). This complication was higher following a primary anastomosis (6 of 26 patients: 23%), compared with a delayed anastomosis (1 of 16 patients: 6.3%). Patients were followed up for a median of 7 years (range 3 months-20 years) and questioned with regard to their quality of life. Cumulative reoperation rates at 5 years were 55%, and at 10 years were 74%. Most patients assessed following surgery enjoyed an unrestricted social life and none would contemplate the alternative of an ileostomy. The study suggests that despite the high incidence of recurrence, the quality of life following surgery can be good and supports the view that colectomy and ileorectal anastomosis can be used as an alternative to proctocolectomy in the treatment of Crohn's colitis for a select group of patients.
对42例因克罗恩病性结肠炎接受结肠切除术和回肠直肠吻合术(IRA)的患者进行了研究,这些患者的直肠基本未受累。手术死亡率为7%(3例患者),且每位患者均因吻合口破裂死亡。吻合口破裂的总体发生率为16.7%(7例患者)。与延迟吻合(16例患者中的1例:6.3%)相比,一期吻合后该并发症的发生率更高(26例患者中的6例:23%)。对患者进行了中位时间为7年(范围3个月至20年)的随访,并询问了他们的生活质量。5年时的累积再次手术率为55%,10年时为74%。大多数术后接受评估的患者享有不受限制的社交生活,且没有人会考虑选择回肠造口术。该研究表明,尽管复发率很高,但手术后的生活质量可以良好,并支持这样一种观点,即对于特定患者群体,结肠切除术和回肠直肠吻合术可作为全直肠结肠切除术治疗克罗恩病性结肠炎的替代方法。