用6-羟基多巴胺处理后雏鸡心血管系统去甲肾上腺素能神经支配的再生
Regeneration of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6-hydroxydopamine.
作者信息
Bennett T, Malmfors T
出版信息
J Physiol. 1974 Oct;242(2):517-32. doi: 10.1113/jphysiol.1974.sp010721.
Abstract
- Fluorescence histochemical and pharmacological studies were made of the noradrenergic innervation of inferior venae cavae and left atria from 2- and 6-week-old chicks before, and following, treatment with 6-hydroxydopamine.2. Noradrenergic nerves in the younger animals appeared to be relatively resistant to the toxic effects of 6-hydroxydopamine.3. In the older animals, the time course of recovery from the effects of 6-hydroxydopamine appeared to reflect the rate of regeneration of destroyed noradrenergic nerves.4. Marked presynaptic supersensitivity to adrenaline and noradrenaline was observed in left atria and inferior venae cavae following treatment with 6-hydroxydopamine.
摘要
对2周龄和6周龄雏鸡的下腔静脉和左心房去甲肾上腺素能神经支配进行了荧光组织化学和药理学研究，研究在6-羟基多巴胺处理之前和之后进行。
较年幼动物的去甲肾上腺素能神经似乎对6-羟基多巴胺的毒性作用具有相对抗性。
在较年长动物中，从6-羟基多巴胺作用中恢复的时间进程似乎反映了被破坏的去甲肾上腺素能神经的再生速率。
在6-羟基多巴胺处理后，在左心房和下腔静脉中观察到对肾上腺素和去甲肾上腺素明显的突触前超敏反应。
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Regeneration of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6-hydroxydopamine.用6-羟基多巴胺处理后雏鸡心血管系统去甲肾上腺素能神经支配的再生
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Correlation of norepinephrine content with observations of adrenergic nerves after a single dose of 6-hydroxydopamine in the rat.大鼠单次注射6-羟基多巴胺后去甲肾上腺素含量与肾上腺素能神经观察结果的相关性
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