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The consequences of loss followed by recovery of noradrenergic nerve function on muscarinic receptors in the chick expansor secundariorum muscle.去甲肾上腺素能神经功能丧失后恢复对雏鸡次级扩张肌中毒蕈碱受体的影响。
Br J Pharmacol. 1987 Apr;90(4):635-9. doi: 10.1111/j.1476-5381.1987.tb11215.x.
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The effects of noradrenergic denervation on muscarinic receptors of smooth muscle.去甲肾上腺素能神经支配缺失对平滑肌毒蕈碱受体的影响。
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本文引用的文献

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Supersensitivity and subsensitivity to sympathomimetic amines.对拟交感胺的超敏反应和低敏反应。
Pharmacol Rev. 1963 Jun;15:225-76.
2
Comparison of the effects of chloroquine quinacrine and quinidine on autonomic neuroeffector mechanisms.
Med Biol. 1982 Dec;60(6):307-15.
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The effects of noradrenergic denervation on muscarinic receptors of smooth muscle.去甲肾上腺素能神经支配缺失对平滑肌毒蕈碱受体的影响。
Br J Pharmacol. 1982 May;76(1):177-83. doi: 10.1111/j.1476-5381.1982.tb09204.x.
4
Comparison of the effects of chronic chloroquine treatment and denervation on noradrenergic mechanisms.
Med Biol. 1982 Feb;60(1):25-23.
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Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines.对拟交感胺超敏和低敏的机制。
Pharmacol Rev. 1966 Mar;18(1):629-40.
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Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution.
J Pharmacol Exp Ther. 1968 Jan;159(1):49-58.
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The requriement of sympathetic innervation for the active transport of norepinephrine by the heart.心脏对去甲肾上腺素主动转运的交感神经支配需求。
J Pharmacol Exp Ther. 1968 Jan;159(1):59-65.
8
Supersensitivity of the isolated rat heart after chemical sympathectomy with 6-hydroxydopamine.用6-羟基多巴胺进行化学性交感神经切除术后离体大鼠心脏的超敏反应
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9
A comparison of the sensitivities of innervated and denervated rat vasa deferentia to agonist drugs.支配神经和去神经大鼠输精管对激动剂药物敏感性的比较。
Br J Pharmacol. 1970 Aug;39(4):748-54. doi: 10.1111/j.1476-5381.1970.tb09901.x.
10
The adrenergic nervous system of the domestic fowl (Gallus domesticus [L.]).家鸡（原鸡[L.]）的肾上腺素能神经系统。
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去甲肾上腺素能神经功能丧失后恢复对雏鸡次级扩张肌中毒蕈碱受体的影响。

The consequences of loss followed by recovery of noradrenergic nerve function on muscarinic receptors in the chick expansor secundariorum muscle.

作者信息

Lot T Y

出版信息

Br J Pharmacol. 1987 Apr;90(4):635-9. doi: 10.1111/j.1476-5381.1987.tb11215.x.

DOI:10.1111/j.1476-5381.1987.tb11215.x
PMID:3107647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1917202/
Abstract

The effects of chemical sympathectomy with 6-hydroxydopamine on the response of the expansor secundariorum muscle to noradrenergic nerve stimulation, noradrenaline and acetylcholine have been investigated. Expansor muscles from 60 day old chicks were sensitive to noradrenergic nerve stimulation and exogenous noradrenaline but virtually unresponsive to acetylcholine. Chemical sympathectomy with 6-hydroxydopamine caused loss of function of noradrenergic nerves of the expansor muscle, induced supersensitivity to exogenous noradrenaline and gradually increased the response of the expansor muscle to acetylcholine. As the patency of noradrenergic nerves reappeared there was a decline in the extent of supersensitivity to noradrenaline and the response to acetylcholine gradually declined. The time courses of these changes differed, indicating that the mechanisms responsible for changes in response to noradrenaline and acetycholine are different.

摘要

研究了用6-羟基多巴胺进行化学性交感神经切除术对次级扩张肌对去甲肾上腺素能神经刺激、去甲肾上腺素和乙酰胆碱反应的影响。60日龄雏鸡的扩张肌对去甲肾上腺素能神经刺激和外源性去甲肾上腺素敏感，但对乙酰胆碱几乎无反应。用6-羟基多巴胺进行化学性交感神经切除术导致扩张肌去甲肾上腺素能神经功能丧失，对外源性去甲肾上腺素产生超敏反应，并逐渐增加扩张肌对乙酰胆碱的反应。随着去甲肾上腺素能神经通畅性的恢复，对去甲肾上腺素的超敏反应程度下降，对乙酰胆碱的反应逐渐降低。这些变化的时间进程不同，表明负责对去甲肾上腺素和乙酰胆碱反应变化的机制不同。