Cherksey B D, Altszuler N
Pharmacology. 1974;12(6):362-71. doi: 10.1159/000136560.
Injection of thiopental sodium, 25 or 40 mg/kg, i.p., into normal rats produced a prompt sleep which lasted 8.3 plus or minus 2.9 and 16.8 plus or minus 2.7 min, respectively. Injection of morphine sulphage, 20 mg/kg, i.p., itself produced only mild sedation but prolonged the thiopental induced sleep to 50 and 67.3 min, respectively. At 1 min after onset of sleep the brain thiopental concentration in morphine pretreated animals was significantly lower than in control animals. Furthermore the latter also awoke with higher brain thiopental concentrations; the morphine pretreated animals slept for a longer time despite lower brain thiopental concentration. The t1/2 of brain thiopental was longer in the morphine pretreated animals, 25 min, than in the control animals, 9 min. Distribution of thiopental in several tissues at various time periods following injection of thiopental revealed some time-related quantitative differences between the two groups but a similar qualitative pattern. It is suggested that morphine lowers the brain threshold for thiopental induced sleep.
给正常大鼠腹腔注射25或40毫克/千克的硫喷妥钠，分别产生了持续8.3±2.9分钟和16.8±2.7分钟的快速睡眠。腹腔注射20毫克/千克的硫酸吗啡本身仅产生轻度镇静作用，但分别将硫喷妥钠诱导的睡眠时间延长至50分钟和67.3分钟。在睡眠开始后1分钟，吗啡预处理动物的脑硫喷妥钠浓度显著低于对照动物。此外，后者醒来时脑硫喷妥钠浓度也更高；吗啡预处理动物尽管脑硫喷妥钠浓度较低，但睡眠时间更长。吗啡预处理动物脑硫喷妥钠的半衰期为25分钟，比对照动物的9分钟更长。注射硫喷妥钠后不同时间段硫喷妥钠在几种组织中的分布显示，两组之间存在一些与时间相关的定量差异，但定性模式相似。提示吗啡降低了硫喷妥钠诱导睡眠的脑阈值。
