Chakrabarti S K
J Toxicol Environ Health. 1981 May;7(5):765-74. doi: 10.1080/15287398109530018.
Pretreatment with HgCl2 (2 mg/kg sc) 24 h before administration of thiopental (35 mg/kg ip) significantly potentiated the duration of thiopental sleeping time in adult male rats but did not influence the onset time for anesthesia. The plasma concentration of free thiopental was significantly higher in the Hg-treated animals 15 and 45 min after thiopental injection (i.e., during the period of thiopental anesthesia), with a concomitant increase of the free thiopental concentration in the brain at 15 min. However, total and free brain thiopental concentrations in Hg-treated rats at the time of awakening were not different from those in saline-treated animals. Urinary thiopental remained unchanged from 0 to 2 h, but was increased in the treated urine from 0 to 27 h. In vitro studies showed a strong inhibition of thiopental binding in 24-h Hg-treated plasma. The results suggest that the prolongation of thiopental anesthesia induced by Hg pretreatment is probably related to changes in the disposition of thiopental in the plasma and brain rather than to an alteration in the sensitivity of the central nervous system.
在腹腔注射硫喷妥钠（35毫克/千克）前24小时，皮下注射HgCl2（2毫克/千克）对成年雄性大鼠进行预处理，可显著延长硫喷妥钠的睡眠时间，但不影响麻醉诱导时间。硫喷妥钠注射后15分钟和45分钟（即硫喷妥钠麻醉期间），Hg处理组动物的血浆游离硫喷妥钠浓度显著更高，同时在15分钟时大脑中的游离硫喷妥钠浓度也相应增加。然而，Hg处理组大鼠苏醒时大脑中硫喷妥钠的总量和游离量与生理盐水处理组动物并无差异。硫喷妥钠在0至2小时的尿排泄量保持不变，但在处理后的尿液中，0至27小时的排泄量增加。体外研究表明，经Hg处理24小时的血浆对硫喷妥钠的结合有强烈抑制作用。结果表明，Hg预处理诱导的硫喷妥钠麻醉延长可能与硫喷妥钠在血浆和大脑中的处置变化有关，而非中枢神经系统敏感性的改变。
