既往有胆结石患者胆囊切除术后肝胆汁成分的变化
Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones.
作者信息
Boyer J L, Bloomer J R, Maddrey W C, Tilson D
出版信息
Yale J Biol Med. 1974 Dec;47(4):211-7.
The composition of fasting hepatic bile was analyzed in 63 samples from 8 patients following cholecystectomy to determine if bile was lithogenic in patients with previous cholesterol gallstones after removal of the gallbladder. Bile specimens were obtained from t-tubes over a 7-20 day study period following re-establishment of the enterohepatic circulation. Bile composition varied on a day to day basis in each patient. 18 of 63 samples were lithogenic according to criteria of Admirand and Small while 35 of 63 samples were lithogenic according to criteria of Hegardt and Dam. Variations in the composition of hepatic bile appeared related to changes in the excretion rate of bile acids. These studies demonstrate that hepatic bile may be lithogenic after cholecystectomy and indicate that factors other than sequestration of the bile acid pool in the gallbladder influence the enterohepatic circulation of bile acids and the lithogenicity of bile.
对8例胆囊切除术后患者的63份空腹肝胆汁样本进行分析，以确定既往有胆固醇结石的患者在胆囊切除后胆汁是否具有致石性。在肠肝循环重建后的7 - 20天研究期内，通过T管获取胆汁样本。每位患者的胆汁成分每天都有所不同。根据Admirand和Small的标准，63份样本中有18份具有致石性；根据Hegardt和Dam的标准，63份样本中有35份具有致石性。肝胆汁成分的变化似乎与胆汁酸排泄率的变化有关。这些研究表明，胆囊切除术后肝胆汁可能具有致石性，并表明除胆囊中胆汁酸池的潴留外，其他因素也会影响胆汁酸的肠肝循环和胆汁的致石性。
Zotero 插件