胆固醇胆结石患者胆汁异常间歇性分泌。
Intermittent secretion of abnormal bile in patients with cholesterol gall stones.
作者信息
Smallwood R A, Jablonski P, Watts J M
出版信息
Br Med J. 1972 Nov 4;4(5835):263-6. doi: 10.1136/bmj.4.5835.263.
Abstract
Gall bladder and hepatic bile was sampled from 66 patients undergoing elective operations on the biliary tract. Fifty-one patients had cholesterol gall stones but only 59% of these were found to have bile which was supersaturated with cholesterol. Repeated sampling of hepatic bile from patients with T-tubes showed that the secretion of supersaturated bile was intermittent.These results indicate that it is impossible to separate patients with cholesterol stones from controls simply by examination of the lipid composition of their bile, since an appreciable number of bile samples from patients with cholesterol stones were unsaturated.The fact that cholesterol gall stones form when the bile is supersaturated with cholesterol only intermittently suggests that the gall bladder may also have a part in their formation.
摘要
从66例接受择期胆道手术的患者中采集胆囊胆汁和肝胆汁样本。51例患者有胆固醇胆结石，但其中只有59%的患者胆汁中胆固醇呈过饱和状态。对带有T形管的患者反复采集肝胆汁样本显示，过饱和胆汁的分泌是间歇性的。这些结果表明，仅通过检查胆汁的脂质成分，无法将胆固醇结石患者与对照组区分开来，因为相当数量的胆固醇结石患者的胆汁样本不饱和。胆固醇胆结石仅在胆汁间歇性过饱和时形成，这一事实表明胆囊在其形成过程中可能也起到了一定作用。
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