一种用于常规测定萘普生的紫外分光光度法。
An ultraviolet spectrophotometric procedure for the routine determination of naproxen.
作者信息
Holzbecher M, Ellenberger H A, Marsh J M, Boudreau S
出版信息
Clin Biochem. 1979 Apr;12(2):66-7. doi: 10.1016/s0009-9120(79)80010-7.
PMID:445798
Abstract
- A procedure for the routine assay of Naproxen in serum by ultraviolet spectrophotometry is presented. The absorption coefficient (A1 1% cm) of Naproxen in methanol at 261 nm was found to be 216. 2. The Naproxen procedure appears to be relatively free from interferences of commonly coadministered medications. Salicylate interference is eliminated by a modified procedure. 3. Concentrations of Naproxen in a limited number (40) of clinical samples ranged from non-detected to 12.5 mg/dl. The therapeutic concentration appears to be 4 to 6 mg/dl (174-260 mumol/L).
摘要
- 介绍了一种用紫外分光光度法常规测定血清中萘普生的方法。发现萘普生在甲醇中于261nm处的吸收系数（A1 1% cm）为216。2. 萘普生测定方法似乎相对不受常用合并用药的干扰。通过改进的方法可消除水杨酸盐的干扰。3. 有限数量（40个）临床样本中萘普生的浓度范围为未检测到至12.5mg/dl。治疗浓度似乎为4至6mg/dl（174 - 260μmol/L）。
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