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甜菜碱的抗惊厥特性。

Anticonvulsant properties of betaine.

作者信息

Freed W J, Gillin J C, Wyatt R J

出版信息

Epilepsia. 1979 Jun;20(3):209-13. doi: 10.1111/j.1528-1157.1979.tb04797.x.

DOI:10.1111/j.1528-1157.1979.tb04797.x
PMID:446432
Abstract

It has been shown previously that convulsions induced by homocysteine are blocked by betaine. In the present study, betaine was found to block the induction of convulsions by electroconvulsive shock and by pentylenetetrazol at least at effectively as it blocked convulsions induced by homocysteine. Thus, betaine has a general anticonvulsant action, the reason for which is unknown.

摘要

先前已经表明,甜菜碱可阻断同型半胱氨酸诱发的惊厥。在本研究中,发现甜菜碱至少能像阻断同型半胱氨酸诱发的惊厥一样有效地阻断电惊厥休克和戊四氮诱发的惊厥。因此,甜菜碱具有一般的抗惊厥作用,其原因尚不清楚。

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Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.神经元产生的甜菜碱通过配体门控离子通道发挥作用,以控制行为状态。
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