Johnson R N, Charlton J D, Englander R N, Brickley J J, Nowack W J, Hanna G R
Epilepsia. 1979 Jun;20(3):247-54. doi: 10.1111/j.1528-1157.1979.tb04801.x.
Regional effects of electrical stimulation of the cerebellar surface were quantitatively analyzed. Computer controlled stimulus sequences were delivered to ventrolateral thalamus and evoked responses recorded from ipsilateral sensorimotor cortex in the cat. Threshold and excitability profiles were produced with an on-line computer, and their modification by cerebellar stimulation was determined. The results of electrical stimulation of the cerebellar surface were: (1) depressed excitability from paramedian lobule and lobulus simplex; (2) uniquely elevated thresholds from paramedian lobule; and (3) a profound and long-lasting depression of excitability following termination of lobulus simplex stimulation. In comparison with our anticonvulsant drug studies, these data suggest that cerebellar surface stimulation has a far greater capacity to control excitability and threshold responsiveness of thalamocortical systems. Cerebellar electrode placement and temporal pattern of stimulation appear to be important factors in the production of antiepileptic effects.
对小脑表面电刺激的区域效应进行了定量分析。通过计算机控制的刺激序列施加于猫的腹外侧丘脑，并记录同侧感觉运动皮层诱发的反应。利用在线计算机生成阈值和兴奋性分布图，并确定小脑刺激对其的改变。小脑表面电刺激的结果如下：（1）来自旁中央小叶和简单小叶的兴奋性降低；（2）来自旁中央小叶的阈值独特升高；（3）简单小叶刺激终止后兴奋性出现深刻且持久的降低。与我们的抗惊厥药物研究相比，这些数据表明小脑表面刺激在控制丘脑皮质系统的兴奋性和阈值反应性方面具有更大的能力。小脑电极的放置和刺激的时间模式似乎是产生抗癫痫作用的重要因素。
