Shigeto N, Irisawa H
Jpn J Physiol. 1974 Dec;24(6):605-16. doi: 10.2170/jjphysiol.24.605.
The resting potential of various parts of the AV nodal regions of an excised rabbit heart was changed by applying constant electrical current with a suction electrode. The membrane potential was recorded with an intracellular microelectrode and the maximum rate of rise of depolarization was computed. The action potential recorded from the AV nodal cell responded to constant current in a manner qualitatively similar to other myocardiums. The relationship between resting potential and amplitude of action potential was expressed by a straight line, while a sigmoidal relationship was observed between the resting potential and the maximum rate of rise of depolarization. Most of the initial current system in alpha region was inactivated at the control membrane potential. The maximum value of the maximum rate of rise of depolarization of alpha region was 30 V/sec which was lower than that of other parts of the nodal region.
通过使用吸引电极施加恒定电流，改变了离体兔心脏房室结区域各部分的静息电位。用细胞内微电极记录膜电位，并计算去极化的最大上升速率。从房室结细胞记录的动作电位对恒定电流的反应在性质上与其他心肌相似。静息电位与动作电位幅度之间的关系由一条直线表示，而在静息电位与去极化最大上升速率之间观察到一种S形关系。α区域的大部分初始电流系统在对照膜电位时失活。α区域去极化最大上升速率的最大值为30V/秒，低于结区域其他部分。
