用环磷酰胺治疗活动性慢性肝炎。
Treatment of active chronic hepatitis with cyclophosphamide.
作者信息
Naccarato R, Farini R, Chiaramonte M, Fagiolo U, Sturniolo G C
出版信息
Postgrad Med J. 1974 Jan;50(579):16-24. doi: 10.1136/pgmj.50.579.16.
Twenty patients with active chronic hepatitis, classified on the basis of the treatment into three groups, have been studied: (1) patients treated with cyclophosphamide (10 patients); (2) patients treated with cyclophosphamide after cycles of corticosteroid therapy (four patients); (3) patients treated with corticosteroid (six patients). In all patients we observed clinical, biochemical and immunological changes during and after treatment. Hepatic needle-biopsy was performed in all patients before treatment. The histological picture was rechecked after the first cycle of therapy in twelve patients. The results obtained in the three groups of patients have been statistically compared. Cyclophosphamide treatment produces an improvement of general conditions and a persistent normalization of several biochemical and immunological data, especially in those patients in which active chronic hepatitis was not in an advanced stage (type A aggressive form). The histological picture showed no changes after treatment.
20例活动性慢性肝炎患者，根据治疗方法分为三组进行研究：（1）接受环磷酰胺治疗的患者（10例）；（2）在接受皮质类固醇治疗周期后接受环磷酰胺治疗的患者（4例）；（3）接受皮质类固醇治疗的患者（6例）。我们观察了所有患者在治疗期间及治疗后的临床、生化和免疫学变化。所有患者在治疗前均进行了肝穿刺活检。12例患者在第一个治疗周期后重新检查了组织学图像。对三组患者获得的结果进行了统计学比较。环磷酰胺治疗可改善一般状况，并使多项生化和免疫学数据持续正常化，尤其是在那些活动性慢性肝炎未处于晚期（A型侵袭性形式）的患者中。治疗后组织学图像无变化。
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