Löw O, Machnik G
Arch Exp Veterinarmed. 1974;28(5):725-30.
Administration of TURISYNCHRON (metallibure) to dogs at 1 mg/kg/day for six months did not affect the histological structure of the thyroid, but the volume of nuclei of thyroid epithelial cells was reduced by one-third. In pigs given 100 mg/animal daily for 100 days, this nuclear contraction amounted to only 11%. Metallibure zinc complex (TURISYNCHRON-Z, SUISYNCHRON) given at 1 and 10 mg/kg/day for six months had a similar action on the thyroid.
以1毫克/千克/天的剂量给狗服用图里辛同步剂(美他利脲)六个月,对甲状腺的组织结构没有影响,但甲状腺上皮细胞核的体积减少了三分之一。在每天给猪服用100毫克/只,持续100天的情况下,这种核收缩仅为11%。以1毫克/千克/天和10毫克/千克/天的剂量给狗服用美他利脲锌络合物(图里辛同步剂-Z,猪同步剂)六个月,对甲状腺有类似作用。