大鼠组织中肉碱和三甲氨基丁酸的合成
Carnitine and trimethylaminobutyrate synthesis in rat tissues.
作者信息
Cox R A, Hoppel C L
出版信息
Biochem J. 1974 Sep;142(3):699-701. doi: 10.1042/bj1420699.
Abstract
Liver and testis slices convert 6-N-trimethyl-lysine into 4-N-trimethylaminobutyrate and carnitine. Adipose, skeletal muscle, heart, or kidney tissues metabolize trimethyl-lysine into trimethylaminobutyrate but not into carnitine. Trimethylaminobutyrate hydroxylation, forming carnitine, occurs in liver and to a minor degree in testis. Liver is the primary site of carnitine biosynthesis in the rat.
摘要
肝脏和睾丸切片可将6-N-三甲基赖氨酸转化为4-N-三甲基氨基丁酸酯和肉碱。脂肪组织、骨骼肌、心脏或肾脏组织可将三甲基赖氨酸代谢为三甲基氨基丁酸酯，但不能代谢为肉碱。三甲基氨基丁酸酯的羟基化反应形成肉碱，该反应发生在肝脏中，在睾丸中程度较小。在大鼠体内，肝脏是肉碱生物合成的主要部位。
相似文献
1
Carnitine and trimethylaminobutyrate synthesis in rat tissues.大鼠组织中肉碱和三甲氨基丁酸的合成
Biochem J. 1974 Sep;142(3):699-701. doi: 10.1042/bj1420699.
2
Effect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig.维生素C缺乏对豚鼠体内三甲氨基丁酸羟化生成肉碱的影响。
Biochim Biophys Acta. 1984 Jan 24;797(1):136-9. doi: 10.1016/0304-4165(84)90392-1.
3
Effect of ascorbic acid deficiency on the in vivo synthesis of carnitine.
Biochim Biophys Acta. 1981 Jan 7;672(1):123-7. doi: 10.1016/0304-4165(81)90286-5.
4
Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from 6-N-trimethyl-lysine.由N6-三甲基赖氨酸合成肉碱和4-N-三甲基氨基丁酸
Biochem J. 1973 Dec;136(4):1083-90. doi: 10.1042/bj1361083.
5
Carnitine synthesis in rat tissue slices.大鼠组织切片中的肉碱合成
Biochem Biophys Res Commun. 1974 Feb 4;56(3):676-81. doi: 10.1016/0006-291x(74)90658-5.
6
Transport and metabolism of carnitine precursors in various organs of the rat.
Biochim Biophys Acta. 1980 Aug 1;631(1):192-202. doi: 10.1016/0304-4165(80)90067-7.
7
Turnover of carnitine by rat tissues.大鼠组织中肉碱的周转
Biochem J. 1975 Jun;148(3):439-45. doi: 10.1042/bj1480439.
8
Propionylcarnitine. Physiological variations in vivo.丙酰肉碱。体内的生理变化。
Biochim Biophys Acta. 1968 May 1;152(3):559-67. doi: 10.1016/0005-2760(68)90096-9.
9
Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from lysine.由赖氨酸合成肉碱和4-N-三甲基氨基丁酸。
Biochem J. 1973 Dec;136(4):1075-82. doi: 10.1042/bj1361075.
10
Effect of physical training on carnitine concentration in liver, heart and gastrocnemius muscle of rat.体育锻炼对大鼠肝脏、心脏和腓肠肌中肉碱浓度的影响。
Int J Vitam Nutr Res. 1980;50(1):40-3.
引用本文的文献
1
The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion.链脲佐菌素诱导糖尿病及胰岛素治疗对肉碱生物合成和肾脏排泄的影响。
Molecules. 2021 Nov 15;26(22):6872. doi: 10.3390/molecules26226872.
2
Carnitine biosynthesis in mammals.哺乳动物中的肉碱生物合成。
Biochem J. 2002 Feb 1;361(Pt 3):417-29. doi: 10.1042/0264-6021:3610417.
3
Carnitine biosynthesis. Hydroxylation of N6-trimethyl-lysine to 3-hydroxy-N6-trimethyl-lysine.肉碱生物合成。N6-三甲基赖氨酸羟基化为3-羟基-N6-三甲基赖氨酸。
Biochem J. 1980 May 15;188(2):529-34. doi: 10.1042/bj1880529.
4
N6-Trimethyl-lysine metabolism. 3-Hydroxy-N6-trimethyl-lysine and carnitine biosynthesis.N6-三甲基赖氨酸代谢。3-羟基-N6-三甲基赖氨酸与肉碱的生物合成。
Biochem J. 1980 May 15;188(2):509-19. doi: 10.1042/bj1880509.
5
gamma-butyrobetaine in tissues and serum of fed and starved rats determined by an enzymic radioisotopic procedure.用酶促放射性同位素法测定喂食和饥饿大鼠组织及血清中的γ-丁甜菜碱。
Biochem J. 1984 Jun 15;220(3):701-6. doi: 10.1042/bj2200701.
6
Lipid intermediates in chronically volume-overloaded rat hearts. Effect of diffuse ischemia.慢性容量超负荷大鼠心脏中的脂质中间体。弥漫性缺血的影响。
Pflugers Arch. 1984 Nov;402(3):317-20. doi: 10.1007/BF00585516.
7
Variation in tissue carnitine concentrations with age and sex in the rat.大鼠体内组织肉碱浓度随年龄和性别的变化。
Biochem J. 1978 Dec 15;176(3):677-81. doi: 10.1042/bj1760677.
本文引用的文献
1
Carnitine and derivatives in rat tissues.肉碱及其衍生物在大鼠组织中的分布。
Biochem J. 1967 Dec;105(3):953-63. doi: 10.1042/bj1050953.
2
ENZYMOLOGICAL DETERMINATION OF FREE CARNITINE CONCENTRATIONS IN RAT TISSUES.大鼠组织中游离肉碱浓度的酶学测定
J Lipid Res. 1964 Apr;5:184-7.
3
Carnitine.肉碱
Vitam Horm. 1957;15:73-118. doi: 10.1016/s0083-6729(08)60508-7.
4
Age-dependency of various protein methylases.各种蛋白质甲基化酶的年龄依赖性。
Exp Gerontol. 1971 Aug;6(4):271-7. doi: 10.1016/0531-5565(71)90008-8.
5
Protein methylation.蛋白质甲基化
Science. 1971 Oct 8;174(4005):114-9. doi: 10.1126/science.174.4005.114.
6
Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from 6-N-trimethyl-lysine.由N6-三甲基赖氨酸合成肉碱和4-N-三甲基氨基丁酸
Biochem J. 1973 Dec;136(4):1083-90. doi: 10.1042/bj1361083.
7
Biosynthesis of carnitine and 4-N-trimethylaminobutyrate from lysine.由赖氨酸合成肉碱和4-N-三甲基氨基丁酸。
Biochem J. 1973 Dec;136(4):1075-82. doi: 10.1042/bj1361075.
8
Hydroxylation of gamma-butyrobetaine to carnitine in rat liver.大鼠肝脏中γ-丁酸甜菜碱羟基化为肉碱的过程。
Biochemistry. 1967 May;6(5):1271-82. doi: 10.1021/bi00857a007.
9
Role of lysine and -N-trimethyllysine in carnitine biosynthesis. I. Studies in Neurospora crassa.赖氨酸和-N-三甲基赖氨酸在肉碱生物合成中的作用。I. 粗糙脉孢菌的研究。
J Biol Chem. 1973 Mar 25;248(6):2170-5.
Zotero 插件