用N-乙基-N-(4-羟基丁基)亚硝胺及其主要尿代谢物在大鼠中快速选择性诱导膀胱癌 - Suppr

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Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite.

作者信息

Hashimoto Y, Iiyoshi M, Okada M

出版信息

Gan. 1974 Dec;65(6):565-6.

PMID:4465158

Abstract

摘要

相似文献

Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite.用N-乙基-N-(4-羟基丁基)亚硝胺及其主要尿代谢物在大鼠中快速选择性诱导膀胱癌

Gan. 1974 Dec;65(6):565-6.

Induction of urinary bladder tumors by intravesicular instillation of butyl(4-hydroxybutyl)nitrosoamine and its principal urinary metabolite, butyl(3-carboxypropyl)nitrosoamine in rats.

Gan. 1974 Feb;65(1):69-73.

Metabolic fate of N-butyl-N-(4-hydroxybutyl)nitrosamine homologs in the rat, in relation to their organotropic carcinogenicity to the urinary bladder.大鼠体内 N-丁基-N-(4-羟基丁基)亚硝胺同系物的代谢命运，及其对膀胱的器官特异性致癌性

Gan. 1981 Feb;72(1):113-22.

Metabolic fate of N-alkyl-N-(3-hydroxypropyl and 2-hydroxy-ethyl)nitrosamines in the rat in relation to the induction of bladder cancer by N-butyl-N-(4-hydroxybutyl)nitrosamine and its homologs.大鼠体内N-烷基-N-(3-羟丙基和2-羟乙基)亚硝胺的代谢命运与N-丁基-N-(4-羟丁基)亚硝胺及其同系物诱发膀胱癌的关系。

Gan. 1981 Apr;72(2):254-8.

Metabolic fate and carcinogenicity of N-(omega-hydroxyalkyl) N-(4-hydroxybutyl) nitrosamines analogs of N-butyl-N-(4-hydroxy-butyl) nitrosamine, in the rat.大鼠体内N-丁基-N-（4-羟丁基）亚硝胺的N-（ω-羟烷基）N-（4-羟丁基）亚硝胺类似物的代谢命运和致癌性

Gan. 1981 Aug;72(4):539-46.

Induction of urinary bladder tumors in ACI-N rats by butyl(3-carboxypropyl)nitrosoamine, a major urinary metabolite of butyl-(4-hydroxybutyl)nitrosoamine.

Gan. 1972 Oct;63(5):637-8.

Metabolism of butyl(4-hydroxybutyl)nitrosoamine in rats.

Gan. 1972 Jun;63(3):391-2.

Comparison of bladder tumors induced in rats and mice with N-butyl-N-(4-hydroxybutyl)-nitrosoamine.

Gan. 1973 Aug;64(4):331-6.

Effect of various factors on induction of urinary bladder tumors in animals by N-butyl-n-(4-hydroxybutyl)nitrosoamine.

Gan. 1973 Apr;64(2):151-9.

Relationship of urinary N-butyl-N-(3-carboxypropyl)nitrosamine to susceptibility of animals to bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.尿中N-丁基-N-（3-羧丙基）亚硝胺与动物对N-丁基-N-（4-羟丁基）亚硝胺诱发膀胱癌易感性的关系。

Gan. 1983 Jun;74(3):360-4.

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Early detection of urinary bladder carcinogens in rats by immunohistochemistry for γ-H2AX: a review from analyses of 100 chemicals.通过γ-H2AX免疫组织化学早期检测大鼠膀胱致癌物：对100种化学物质分析的综述

J Toxicol Pathol. 2022 Oct;35(4):283-298. doi: 10.1293/tox.2022-0061. Epub 2022 Aug 18.

Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for γ-H2AX.通过免疫组化检测 γ-H2AX 表达干细胞标志物作为早期检测膀胱癌致癌物的有用补充因子。

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Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.用N-丁基-N-（4-羟丁基）亚硝胺启动大鼠膀胱，随后给予膀胱致癌物和促癌剂，部分膀胱切除术对诱导大鼠膀胱癌前病变的影响。

Urol Res. 1982;10(3):115-8. doi: 10.1007/BF00255952.

Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):315-22. doi: 10.1007/BF00305369.

Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.二正丁基亚硝胺的氧化生物转化。在大鼠肝微粒体存在的情况下醛类在体外的形成。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):311-4. doi: 10.1007/BF00305368.

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