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Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.

作者信息

Blattmann L

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):315-22. doi: 10.1007/BF00305369.

DOI:10.1007/BF00305369
PMID:140546
Abstract

Comparative in vivo investigations on the biotransformation of di-n-butylnitrosamine (DBNA) and (2-hydroxybutyl)-n-butylnitrosamine (HBBNA) showed the known omega-oxidation. However, a new metabolic mechanism of direct oxidative alkyl chain cleavage in the vicinity of the hydroxy group of HBBNA could be demonstrated.

摘要

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本文引用的文献

1
Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas.微粒体N-脱甲基作用以及肝脏致癌物二甲基亚硝胺对氨基酸掺入大鼠肝脏和肝癌蛋白质中的影响。
Exp Cell Res. 1960 Apr;19:467-74. doi: 10.1016/0014-4827(60)90056-2.
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Studies in detoxication. 79. The metabolism of cyclo [14C] hexane and its derivatives.解毒研究。79. 环[14C]己烷及其衍生物的代谢
Biochem J. 1959 Jun;72(2):193-200. doi: 10.1042/bj0720193.
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Arzneimittelforschung. 1970 Oct;20(10):1512-7.
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Metabolism of butyl(4-hydroxybutyl)nitrosoamine in rats.
Gan. 1972 Jun;63(3):391-2.
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The metabolism of tetralin.萘满的代谢
Biochem J. 1968 Jul;108(4):551-9. doi: 10.1042/bj1080551.
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Potential alkylating agents from the oxidation of carcinogenic cyclic n-nitrosamines.致癌性环状 N-亚硝胺氧化产生的潜在烷基化剂。
Br J Cancer. 1973 Jul;28(1):84. doi: 10.1038/bjc.1973.101.
7
Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite.用N-乙基-N-(4-羟基丁基)亚硝胺及其主要尿代谢物在大鼠中快速选择性诱导膀胱癌
Gan. 1974 Dec;65(6):565-6.
8
[An enzymatic rearrangement of carcinogenic nitrosamines].
Z Naturforsch B. 1970 Mar;25(3):302-7.
9
[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].[致癌二烷基亚硝胺的大鼠尿液代谢物结构（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):3-5. doi: 10.1007/BF00284333.
10
[Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].[致癌二烷基亚硝胺的生物转化。二正丁基和二正戊基亚硝胺的进一步尿代谢产物（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):75-8. doi: 10.1007/BF00303603.