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二正丁基亚硝胺的氧化生物转化。在大鼠肝微粒体存在的情况下醛类在体外的形成。

Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.

作者信息

Blattmann L, Preussmann R

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):311-4. doi: 10.1007/BF00305368.

DOI:10.1007/BF00305368
PMID:140545
Abstract

After in vitro incubation of di-n-butylnitrosamine with rat liver microsomes in the presence of the necessary cofactors butyraldehyde has been identified as a reaction product together with smaller amounts of propionaldehyde and acetaldehyde.

摘要

在必要的辅助因子存在的情况下，将二正丁基亚硝胺与大鼠肝微粒体进行体外孵育后，已鉴定出丁醛是反应产物，同时还有少量的丙醛和乙醛。

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引用本文的文献

1
Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):315-22. doi: 10.1007/BF00305369.

本文引用的文献

1
ACTIVATED HYDROGENS IN COMPOUNDS RELATED TO THIAMINE.与硫胺素相关化合物中的活性氢
Biochemistry. 1963 Nov-Dec;2:1298-304. doi: 10.1021/bi00906a022.
2
Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas.微粒体N-脱甲基作用以及肝脏致癌物二甲基亚硝胺对氨基酸掺入大鼠肝脏和肝癌蛋白质中的影响。
Exp Cell Res. 1960 Apr;19:467-74. doi: 10.1016/0014-4827(60)90056-2.
3
Mechanism of 3-methylcholanthrene-induced inhibition of dimethylnitrosamine demethylase in rat liver.
3-甲基胆蒽诱导大鼠肝脏中二甲基亚硝胺脱甲基酶抑制的机制。
Cancer Res. 1970 Oct;30(10):2556-62.
4
Metabolism of butyl(4-hydroxybutyl)nitrosoamine in rats.
Gan. 1972 Jun;63(3):391-2.
5
The use of new methods to measure: the effect of diet and inducers of microsomal enzyme synthesis on cytochrome P-450 in liver homogenates, and on metabolism of dimethyl nitrosamine.采用新方法测量：饮食及微粒体酶合成诱导剂对肝匀浆中细胞色素P - 450以及对二甲基亚硝胺代谢的影响。
Biochem Pharmacol. 1974 Apr 1;23(7):1173-80. doi: 10.1016/0006-2952(74)90291-3.
6
Rapid and selective induction of urinary bladder cancer in rats with N-ethyl-N-(4-hydroxybutyl)nitrosoamine and by its principal urinary metabolite.用N-乙基-N-(4-羟基丁基)亚硝胺及其主要尿代谢物在大鼠中快速选择性诱导膀胱癌
Gan. 1974 Dec;65(6):565-6.
7
Mechanism of carcinogenesis with 1-aryl-3,3-dialkyltriazenes. Enzymatic dealkylation by rat liver microsomal fraction in vitro.1-芳基-3,3-二烷基三氮烯的致癌机制。大鼠肝脏微粒体部分在体外的酶促脱烷基作用。
Biochem Pharmacol. 1969 Jan;18(1):1-13. doi: 10.1016/0006-2952(69)90002-1.
8
[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].[致癌二烷基亚硝胺的大鼠尿液代谢物结构（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):3-5. doi: 10.1007/BF00284333.
9
[Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].[致癌二烷基亚硝胺的生物转化。二正丁基和二正戊基亚硝胺的进一步尿代谢产物（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):75-8. doi: 10.1007/BF00303603.
10
[Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):71-3. doi: 10.1007/BF00303602.