Turner P
Postgrad Med J. 1974 Feb;50(580):93-5. doi: 10.1136/pgmj.50.580.93.
Differences in formulation are of greater clinical importance in the case of sparingly soluble drugs, those with small therapeutic doses, in replacement therapy and in the control of serious clinical conditions with compounds having a low therapeutic index: this subject should receive specific attention in medical teaching and in clinical trials.
对于难溶性药物、治疗剂量小的药物、替代疗法中的药物以及用治疗指数低的化合物控制严重临床病症时,制剂差异具有更大的临床重要性:在医学教学和临床试验中应特别关注这一主题。