Kalbermann L E, Szijan I, Burdman J A
Experientia. 1979 May 15;35(5):689-90. doi: 10.1007/BF01960401.
We investigated the relationship between prolactin content and DNA replication in the anterior pituitary gland. Thymidine incorporation in pregnant rats is significantly lower than in virgin controls. This is accompanied by a decreased activity of DNA polymerase. Sulpiride administration to pregnant rats enhances thymidine incorporation to levels similar to virgin controls. The results indicate a negative feedback between prolactin content and DNA synthesis in the rat anterior pituitary gland.
我们研究了垂体前叶中催乳素含量与DNA复制之间的关系。妊娠大鼠的胸腺嘧啶核苷掺入量显著低于未孕对照大鼠。这伴随着DNA聚合酶活性的降低。给妊娠大鼠注射舒必利可使胸腺嘧啶核苷掺入量提高至与未孕对照大鼠相似的水平。结果表明，大鼠垂体前叶中催乳素含量与DNA合成之间存在负反馈关系。
