Zolotukhin S I, Borisova E O
Farmakol Toksikol. 1979 May-Jun;42(3):247-51.
Nonachlazine at concentrations 10(-6)--10(-4)M inhibited platelet aggregation in rabbits induced by adrenalin in vitro. The same concentrations of the drug produced an appreciable increase in aggregation reversibility. Intravenous injection of nonachlazine into the rabbit 50 minutes prior to adrenalin protected the platelets against the aggregation activity of adrenalin but did not affect deaggregation.
浓度为10⁻⁶ - 10⁻⁴M的去甲氯氮平在体外可抑制肾上腺素诱导的家兔血小板聚集。相同浓度的该药物可使聚集的可逆性显著增加。在给家兔静脉注射肾上腺素前50分钟注射去甲氯氮平,可保护血小板免受肾上腺素的聚集活性影响,但不影响解聚。