Zapadniuk V I, Kuprash L P, Zaika M U, Oranskaia S A
Farmakol Toksikol. 1979 May-Jun;42(3):274-8.
It was established that potassium glutaminate is a little toxic compound (LD50 amounts to 4500 mg/kg on administration to white mice by mouth) and shows a marked pharmacological activity. Administration of potassium glutaminate to white rats in a dose 500 mg/kg raises intracellular potassium level in the tissues, makes the acid-balance equilibrium return to normal after unilateral nephrectomy and acid load, activates bile-forming and choleretic liver function, exerts a moderate diuretic effect. The compound potentiates the activity of succinate dehydrogenase and cytochromoxidase in the tissues of old rats.
已确定谷氨酸钾是一种低毒化合物（经口给予小白鼠时的半数致死量为4500毫克/千克），并具有显著的药理活性。以500毫克/千克的剂量给大白鼠注射谷氨酸钾，可提高组织中的细胞内钾水平，在单侧肾切除和酸负荷后使酸碱平衡恢复正常，激活胆汁生成和利胆的肝功能，发挥适度的利尿作用。该化合物可增强老年大鼠组织中琥珀酸脱氢酶和细胞色素氧化酶的活性。
