Zapadniuk V I, Kuprash L P, Zaika M U, Oranskaia S A
Farmakol Toksikol. 1984 Mar-Apr;47(2):58-61.
Experiments on young and old rabbits and rats were made to study the age-associated features of the pharmacokinetics of a new drug--potassium glutamate developed at the Laboratory of Experimental Pharmacology, Institute of Gerontology, Academy of Medical Sciences of the USSR. The age-associated differences in some pharmacokinetic parameters of potassium glutamate were disclosed: an increase in the half-life, a decrease in the overall clearance and a reduction in the elimination coefficient, an increase in the extent of distribution and area of the pharmacokinetic curve in old animals. A correlation was found between the pharmacokinetic parameters and drug pharmacological activity in animals of different age groups. The use of the pharmacokinetic data made it possible to calculate the optimal doses and to develop the schemes of effective application of potassium glutamate for young and old animals, as well as to extrapolate the experimental data to the drug clinical trials.
在年轻和老年兔及大鼠身上进行了实验，以研究一种新药——谷氨酸钾的药代动力学的年龄相关特征。该药物由苏联医学科学院老年学研究所实验药理学实验室研制。揭示了谷氨酸钾某些药代动力学参数的年龄相关差异：老年动物的半衰期延长、总清除率降低、消除系数减小、分布范围和药代动力学曲线面积增加。在不同年龄组的动物中发现药代动力学参数与药物药理活性之间存在相关性。利用药代动力学数据可以计算出年轻和老年动物使用谷氨酸钾的最佳剂量，并制定有效应用方案，还可以将实验数据外推至药物临床试验。
