Henry R W, Stout R W, Buchanan K D
Diabete Metab. 1979 Mar;5(1):21-6.
The responses of plasma gastro-entero-pancreatic (GEP) hormones and free fatty acids (FFA) to a standard mixed meal before and after starvation have been measured. Raised insulin, glucose and FFA levels were found following refeeding after starvation and levels of secretin and C-terminal glucagon-like-immunoreactivity (C-GLI), raised by starvation, were rapidly suppressed on refeeding. The responses of gastrin and N-terminal glucagon-like-immunoreactivity (N-GLI) to a standard mixed meal were not altered by starvation. Although this study does not directly support that secretin and glucagon are responsible for the hyperglycaemia or hyperinsulinaemia of starvation diabetes, a role for both hormones in the raised FFA levels is proposed, as well as a role for glucagon in the initial hyperglycaemic response to a meal after starvation.
已经测量了饥饿前后血浆胃肠胰（GEP）激素和游离脂肪酸（FFA）对标准混合餐的反应。饥饿后重新进食后发现胰岛素、葡萄糖和FFA水平升高，饥饿时升高的促胰液素和C端胰高血糖素样免疫反应性（C-GLI）水平在重新进食后迅速受到抑制。胃泌素和N端胰高血糖素样免疫反应性（N-GLI）对标准混合餐的反应不受饥饿影响。尽管这项研究没有直接支持促胰液素和胰高血糖素是饥饿性糖尿病高血糖或高胰岛素血症的原因，但提出了这两种激素在升高的FFA水平中起作用，以及胰高血糖素在饥饿后对一餐的初始高血糖反应中起作用。
