Shapiro B, Berelowitz M, Pimstone B L, Kronheim S, Sheppard M
Diabetes. 1979 Mar;28(3):182-4. doi: 10.2337/diab.28.3.182.
Somatostatin-like immunoreactivity (SLI) was measured in extracts of gastric antrum, colon, pancreas, and central nervous system, as well as in unextracted portal and inferior vena caval serum from fed, 15-h-fasted, and 72-h-fasted rats. No differences were found in SLI in the central nervous system of the three groups. However, striking variations were found in the gastrointestinal tract and pancreas; the antrum, colon, and pancreas of 15-h-fasted rats contained the least SLI, the content being significantly elevated in these three areas after feeding and after a 72-h fast. Portal serum levels were highest after feeding but lowest in 72-h-fasted rats, in spite of high intestinal and pancreatic SLI content in both. These tissue and serum differences suggest a physiologic role for SLI in nutrient homeostasis not only at tissue level, but also putatively as a hormone in the portal system.
在喂食、禁食15小时和禁食72小时的大鼠的胃窦、结肠、胰腺和中枢神经系统提取物中，以及未提取的门静脉和下腔静脉血清中，检测了生长抑素样免疫反应性（SLI）。三组大鼠中枢神经系统中的SLI未发现差异。然而，在胃肠道和胰腺中发现了显著变化；禁食15小时的大鼠的胃窦、结肠和胰腺中SLI含量最少，喂食后和禁食72小时后，这三个部位的含量显著升高。尽管喂食后和禁食72小时后肠道和胰腺中的SLI含量都很高，但门静脉血清水平在喂食后最高，而在禁食72小时的大鼠中最低。这些组织和血清差异表明，SLI不仅在组织水平上，而且可能作为门静脉系统中的一种激素，在营养稳态中发挥生理作用。
