Berelowitz M, Pimstone B, Shapiro B, Kronheim S, De Wit D
Clin Endocrinol (Oxf). 1978 Aug;9(2):185-91. doi: 10.1111/j.1365-2265.1978.tb02197.x.
Hypothyroidism in rats was associated with an increase in immuno-reactive GH-RIH in brain, pancreas and gut, although release from the latter may be diminished as portal GH-RIH-like immunoreactivity was lower than control values. Hypophysectomy resulted in a depletion of immunoreactive GH-RIH in the septum and preoptic area of the brain and gastric antrum, but an increase in pancreas; portal venous GH-RIH-like immunoreactivity was not different from control concentrations, possibly reflecting both elevated and lowered immunol-reactive GH-RIH in different regions of tissue subserved by the portal vein. Inferior vena caval GH-RIH-like immunoreactivity was always lower than in the portal vein and was not influenced by tissue pertubations in hypothyroidism and hypopituitarism which made regional blood sampling of great important in evaluating tissue changes.
大鼠甲状腺功能减退与脑、胰腺和肠道中免疫反应性生长抑素释放激素（GH - RIH）增加有关，尽管由于门静脉中类GH - RIH免疫反应性低于对照值，肠道中GH - RIH的释放可能减少。垂体切除术导致脑隔区、视前区和胃窦中免疫反应性GH - RIH减少，但胰腺中增加；门静脉GH - RIH类免疫反应性与对照浓度无差异，这可能反映了门静脉所供应的不同组织区域中免疫反应性GH - RIH既有升高也有降低。下腔静脉类GH - RIH免疫反应性始终低于门静脉，且不受甲状腺功能减退和垂体功能减退时组织扰动的影响，这使得在评估组织变化时区域血样采集非常重要。
