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葡萄糖刺激的胰岛素释放的异头物特异性：存在葡萄糖受体的证据？

Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor?

作者信息

Grodsky G M, Fanska R, West L, Manning M

出版信息

Science. 1974 Nov 8;186(4163):536-8. doi: 10.1126/science.186.4163.536.

DOI:10.1126/science.186.4163.536
PMID:4469677
Abstract

The effects on insulin secretion of alpha and beta anomers of D-glucose were studied in the in vitro perfused rat pancreas. Both phases of insulin release showed consistent stereospecificity for alpha-glucose; this specificity indicates an action of glucose independent of intracellular glucose metabolism.

摘要

在体外灌注大鼠胰腺中研究了D-葡萄糖的α和β异头物对胰岛素分泌的影响。胰岛素释放的两个阶段对α-葡萄糖均表现出一致的立体特异性；这种特异性表明葡萄糖的作用独立于细胞内葡萄糖代谢。

相似文献

1
Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor?葡萄糖刺激的胰岛素释放的异头物特异性：存在葡萄糖受体的证据？
Science. 1974 Nov 8;186(4163):536-8. doi: 10.1126/science.186.4163.536.
2
Interrelationships between alpha and beta-anomers of glucose affecting both insulin and glucagon secretion in the perfused rat pancreas. II.葡萄糖的α和β异头物之间的相互关系对灌注大鼠胰腺中胰岛素和胰高血糖素分泌的影响。II.
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Anomeric specificity of glucose-induced somatostatin secretion.葡萄糖诱导生长抑素分泌的异头特异性。
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Interaction of alloxan and anomers of D-glucose on glucose-induced insulin secretion and biosynthesis in vitro.四氧嘧啶与D-葡萄糖异头物对体外葡萄糖诱导的胰岛素分泌及生物合成的相互作用。
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Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas.
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引用本文的文献

1
Altered anomeric specificity of glucose-induced insulin release in rabbits with duct-ligated pancreas.
Int J Pancreatol. 1991 Feb;8(2):151-67. doi: 10.1007/BF02924429.
2
Insulin release is glucose anomeric specific in the human.在人体中，胰岛素释放具有葡萄糖异头物特异性。
J Clin Invest. 1976 Apr;57(4):1083-8. doi: 10.1172/JCI108351.
3
Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets.大鼠胰岛富含质膜组分的制备与表征
J Cell Biol. 1976 Nov;71(2):606-23. doi: 10.1083/jcb.71.2.606.
4
Comparison of the suppressive effects of elevated plasma glucose and free fatty acid levels on glucagon secretion in normal and insulin-dependent diabetic subjects. Evidence for selective alpha-cell insensitivity to glucose in diabetes mellitus.正常和胰岛素依赖型糖尿病患者中血浆葡萄糖和游离脂肪酸水平升高对胰高血糖素分泌抑制作用的比较。糖尿病中α细胞对葡萄糖选择性不敏感的证据。
J Clin Invest. 1976 Aug;58(2):320-5. doi: 10.1172/JCI108475.
5
Ninhydrin inhibition of glucose-induced insulin release.茚三酮对葡萄糖诱导的胰岛素释放的抑制作用。
Diabetologia. 1977 Dec;13(6):603-6. doi: 10.1007/BF01236314.
6
Anomeric preferences of D-glucose uptake and utilization by cerebral cortex slices of rats.
Neurochem Res. 1979 Aug;4(4):505-16. doi: 10.1007/BF00964644.
7
Adenosine triphosphatases of rat pancreatic islets: comparison with those of rat kidney.大鼠胰岛的三磷酸腺苷酶：与大鼠肾脏的三磷酸腺苷酶比较。
J Clin Invest. 1978 Sep;62(3):692-701. doi: 10.1172/JCI109177.
8
Alloxan cytotoxicity in vitro. Inhibition of rubidium ion pumping in pancreatic beta-cells.四氧嘧啶的体外细胞毒性。对胰腺β细胞中铷离子泵的抑制作用。
Biochem J. 1977 Jan 15;162(1):9-18. doi: 10.1042/bj1620009.
9
The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?葡萄糖诱导的胰岛素释放的刺激-分泌偶联。糖酵解是否控制B细胞中的钙转运？
Biochem J. 1976 Jun 15;156(3):521-5. doi: 10.1042/bj1560521.
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The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release.胰岛中的腺苷酸环化酶 - 环磷酸腺苷系统及其在胰岛素释放控制中的作用。
Diabetologia. 1979 May;16(5):287-96. doi: 10.1007/BF01223617.