用合成鲑鱼降钙素治疗骨佩吉特病。
Treatment of Paget's disease of bone with synthetic salmon calcitonin.
作者信息
Kanis J A, Horn D B, Scott R D, Strong J A
出版信息
Br Med J. 1974 Sep 21;3(5933):727-31. doi: 10.1136/bmj.3.5933.727.
Thirteen patients with painful Paget's disease of bone were treated as outpatients with low doses of synthetic salmon calcitonin 22.5-50 mug three times weekly. Treatment produced full remission of pain in a mean time of 5.5 weeks and a mean depression of serum alkaline phosphatase activity of 33%.The interval before symptomatic relief could not be predicted from the variables studied. The ultimate fall in serum alkaline phosphatase activity, however, could be predicted from the initial levels and from the early rate of decrease (P < 0.001). Biochemical resistance to treatment, which occurred in three cases, could be related to the dose and duration of treatment.Prolonged remissions of pain may occur which are not related to biochemical remission, to the dose of calcitonin, or to the duration of treatment. The side effects attributable to salmon calcitonin were transient nausea (in nine patients), transient flushing (in four), diarrhoea (in two), and rash (in one) though in only one patient did treatment have to be withdrawn prematurely because of these effects.
13例患有疼痛性骨Paget病的患者作为门诊病人接受治疗，每周3次皮下注射低剂量（22.5 - 50微克）的合成鲑鱼降钙素。治疗使疼痛完全缓解的平均时间为5.5周，血清碱性磷酸酶活性平均下降33%。从所研究的变量中无法预测症状缓解前的时间间隔。然而，血清碱性磷酸酶活性的最终下降可以根据初始水平和早期下降速率来预测（P < 0.001）。3例出现对治疗的生化抵抗，这可能与治疗剂量和疗程有关。疼痛可能会长期缓解，这与生化缓解、降钙素剂量或治疗疗程无关。鲑鱼降钙素的副作用包括短暂性恶心（9例）、短暂性面部潮红（4例）、腹泻（2例）和皮疹（1例），不过只有1例患者因这些副作用而不得不提前终止治疗。
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