用光辉霉素治疗骨佩吉特病。
Treatment of Paget's disease of bone with mithramycin.
作者信息
Condon J R, Reith S B, Nassim J R, Millard F J, Hilb A, Stainthorpe E M
出版信息
Br Med J. 1971 Feb 20;1(5746):421-3. doi: 10.1136/bmj.1.5746.421.
Abstract
We report data from three patients with severe Paget's disease of bone who were treated with mithramycin.Mithramycin infusion resulted in a fall in plasma calcium, phosphate, alkaline phosphatase, and urinary hydroxyproline excretion. There was an improvement in calcium and phosphorus balance in two of the three subjects studied. A pronounced or complete relief of bone pain occurred in all three.We suggest that mithramycin exerts its beneficial effect in Paget's disease of bone by stimulating parathyroid hormone release. The parathyroid hormone released has a predominantly anabolic action on bone since its catabolic action is blocked by mithramycin, which inhibits bone resorption.
摘要
我们报告了3例患有严重骨佩吉特病的患者接受光辉霉素治疗的数据。静脉输注光辉霉素导致血浆钙、磷、碱性磷酸酶及尿羟脯氨酸排泄量下降。在研究的3例患者中有2例钙磷平衡得到改善。所有3例患者的骨痛均显著缓解或完全缓解。我们认为，光辉霉素通过刺激甲状旁腺激素释放而在骨佩吉特病中发挥有益作用。所释放的甲状旁腺激素对骨主要起合成代谢作用，因为其分解代谢作用被抑制骨吸收的光辉霉素所阻断。
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Treatment of Paget's disease of bone with mithramycin.用光辉霉素治疗骨佩吉特病。
Br Med J. 1971 Feb 20;1(5746):421-3. doi: 10.1136/bmj.1.5746.421.
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本文引用的文献
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